Drugs show specific pharmacodynamic properties and a plethora of adverse drug reactions
depending on the genetic makeup of their users. Pharmacogenomics explains the variations …

The increased focus on safety in clinical trials represents a formidable hurdle regarding the
availability of marketed drugs. The lengthy experimental process of ensuring the safety of a …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for management of
inflammation and pain, but they can cause gastrointestinal, cardiovascular, and renal …

Nonsteroidal antiinflammatory drugs (NSAIDs) are often metabolized by enzymes of the
cytochrome P450 2C (CYP2C) family, CYP2C9 being the main enzyme involved in the …

Objective To determine whether particular genotypes for the cytochrome P450 enzyme
CYP2D6, a polymorphic enzyme, are associated with susceptibility to rheumatoid arthritis …

Nonsteroidal anti‐inflammatory drugs (NSAIDs) are among the most commonly used
analgesics due to their lack of addictive potential. However, NSAIDs have the potential to …

The aim of this case–control study was to evaluate whether 47 single-nucleotide
polymorphisms (SNPs) in steroid hormone-related genes are associated with the risk of RA …

In vitro studies have demonstrated that at least 18 registered NSAIDs (namely aceclofenac,
aspirin, azapropazone, celecoxib, diclofenac, etodolac, flurbiprofen, ibuprofen …

Highlights•The interindividual variability of CYP2C members and its impact in drug
metabolism are reviewed.•Current advances in molecular modeling of CYP2C …

Pharmacogenomics deals with the study of the variation of the DNA and RNA with the drug
response. DNA polymorphisms play a vital role in the encoding of genes. Several …