[HTML][HTML] Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits
O Peñagarikano, BS Abrahams, EI Herman… - Cell, 2011 - cell.com
Although many genes predisposing to autism spectrum disorders (ASD) have been
identified, the biological mechanism (s) remain unclear. Mouse models based on human …
identified, the biological mechanism (s) remain unclear. Mouse models based on human …
What does CNTNAP2 reveal about autism spectrum disorder?
O Peñagarikano, DH Geschwind - Trends in molecular medicine, 2012 - cell.com
Autism spectrum disorder (ASD) is a phenotypically and genetically heterogeneous
condition characterized by the presence of repetitive/restrictive behaviors and variable …
condition characterized by the presence of repetitive/restrictive behaviors and variable …
Reduced prefrontal synaptic connectivity and disturbed oscillatory population dynamics in the CNTNAP2 model of autism
Loss-of-function mutations in CNTNAP2 cause a syndromic form of autism spectrum
disorder in humans and produce social deficits, repetitive behaviors, and seizures in mice …
disorder in humans and produce social deficits, repetitive behaviors, and seizures in mice …
Selective dysregulation of hippocampal inhibition in the mouse lacking autism candidate gene CNTNAP2
S Jurgensen, PE Castillo - Journal of Neuroscience, 2015 - Soc Neuroscience
Mutations in the human gene encoding contactin-associated protein-like 2 (CNTNAP2) have
been strongly associated with autism spectrum disorders (ASDs). Cntnap2−/− mice …
been strongly associated with autism spectrum disorders (ASDs). Cntnap2−/− mice …
Loss of Cntnap2 in the Rat Causes Autism‐Related Alterations in Social Interactions, Stereotypic Behavior, and Sensory Processing
Autism spectrum disorder (ASD) is characterized by social interaction and communication
impairments, as well as restrictive/repetitive patterns of behavior, interests or activities, which …
impairments, as well as restrictive/repetitive patterns of behavior, interests or activities, which …
Homozygous Loss of Autism-Risk Gene CNTNAP2 Results in Reduced Local and Long-Range Prefrontal Functional Connectivity
Functional connectivity aberrancies, as measured with resting-state functional magnetic
resonance imaging (rsfMRI), have been consistently observed in the brain of autism …
resonance imaging (rsfMRI), have been consistently observed in the brain of autism …
Shining a light on CNTNAP2: complex functions to complex disorders
The genetic basis of complex neurological disorders involving language are poorly
understood, partly due to the multiple additive genetic risk factors that are thought to be …
understood, partly due to the multiple additive genetic risk factors that are thought to be …
Connecting the CNTNAP2 networks with neurodevelopmental disorders
M Poot - Molecular syndromology, 2015 - karger.com
Based on genomic rearrangements and copy number variations, the contactin-associated
protein-like 2 gene (CNTNAP2) has been implicated in neurodevelopmental disorders such …
protein-like 2 gene (CNTNAP2) has been implicated in neurodevelopmental disorders such …
Estrogens suppress a behavioral phenotype in zebrafish mutants of the autism risk gene, CNTNAP2
EJ Hoffman, KJ Turner, JM Fernandez, D Cifuentes… - Neuron, 2016 - cell.com
Autism spectrum disorders (ASDs) are a group of devastating neurodevelopmental
syndromes that affect up to 1 in 68 children. Despite advances in the identification of ASD …
syndromes that affect up to 1 in 68 children. Despite advances in the identification of ASD …
Mouse Cntnap2 and Human CNTNAP2 ASD Alleles Cell Autonomously Regulate PV+ Cortical Interneurons
Human mutations in CNTNAP2 are associated with an array of neuropsychiatric and
neurological syndromes, including speech and language disorders, epilepsy, and autism …
neurological syndromes, including speech and language disorders, epilepsy, and autism …