[HTML][HTML] Role of advanced glycation end products in cellular signaling

C Ott, K Jacobs, E Haucke, AN Santos, T Grune… - Redox biology, 2014 - Elsevier
Improvements in health care and lifestyle have led to an elevated lifespan and increased
focus on age-associated diseases, such as neurodegeneration, cardiovascular disease …

Molecular effects of advanced glycation end products on cell signalling pathways, ageing and pathophysiology

O Nedić, SIS Rattan, T Grune… - Free Radical …, 2013 - Taylor & Francis
Advanced glycation end-products (AGEs) are a heterogeneous group of compounds formed
by the Maillard chemical process of non-enzymatic glycation of free amino groups of …

Does accumulation of advanced glycation end products contribute to the aging phenotype?

RD Semba, EJ Nicklett, L Ferrucci - Journals of Gerontology …, 2010 - academic.oup.com
Background. Aging is a complex multifactorial process characterized by accumulation of
deleterious changes in cells and tissues, progressive deterioration of structural integrity and …

Kidney, heart and brain: three organs targeted by ageing and glycation

M Frimat, M Daroux, R Litke, R Nevière… - Clinical …, 2017 - portlandpress.com
Advanced glycation end-product (AGE) is the generic term for a heterogeneous group of
derivatives arising from a non-enzymatic reaction between reducing sugars and proteins. In …

Clinical/translational aspects of advanced glycation end-products

C Zeng, Y Li, J Ma, L Niu, FR Tay - Trends in Endocrinology & Metabolism, 2019 - cell.com
Advanced glycation end-products (AGEs) have been implicated in chronic hyperglycemia
and age-related diseases. Endogenous AGEs produced by humans generate oxidative …

Food-derived advanced glycation end products (AGEs): a novel therapeutic target for various disorders

S Yamagishi, S Ueda, S Okuda - Current pharmaceutical …, 2007 - ingentaconnect.com
Non-enzymatic modification of proteins by reducing sugars, a process that is also known as
Maillard reaction, leads to the formation of advanced glycation end products (AGEs) in vivo …

[HTML][HTML] Advanced glycation end products: a molecular target for vascular complications in diabetes

S Yamagishi, N Nakamura, M Suematsu, K Kaseda… - Molecular …, 2015 - Springer
A nonenzymatic reaction between reducing sugars and amino groups of proteins, lipids and
nucleic acids contributes to the aging of macromolecules and subsequently alters their …

Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation

R Ramasamy, SJ Vannucci, SSD Yan, K Herold… - …, 2005 - academic.oup.com
The products of nonenzymatic glycation and oxidation of proteins and lipids, the advanced
glycation end products (AGEs), accumulate in a wide variety of environments. AGEs may be …

Advanced glycation end products and their receptor in age-related, non-communicable chronic inflammatory diseases; Overview of clinical evidence and potential …

NL Reynaert, P Gopal, EPA Rutten… - The international journal …, 2016 - Elsevier
Age-related, non-communicable chronic inflammatory diseases represent the major 21st
century health problem. Especially in Western countries, the prevalence of non …

[HTML][HTML] Advanced glycation end-products produced systemically and by macrophages: A common contributor to inflammation and degenerative diseases

K Byun, YC Yoo, M Son, J Lee, GB Jeong… - Pharmacology & …, 2017 - Elsevier
Advanced glycation end products (AGEs) and their receptor have been implicated in the
progressions of many intractable diseases, such as diabetes and atherosclerosis, and are …