The clinical translation of new nanoparticle-based therapies for high-grade glioma (HGG)
remains extremely poor. This has partly been due to the lack of suitable preclinical mouse …

Personalised nanomedicine is an advancing field which has developed significant
improvements for targeting therapeutics to aggressive cancer and with fewer side effects …

The blood–brain barrier represents a significant challenge for the treatment of high-grade
gliomas, and our understanding of drug transport across this critical biointerface remains …

Blood-brain barrier (BBB) disruption is frequently observed in the glioma region. However,
the tumor uptake of drugs is still too low to meet the threshold of therapeutic purpose …

Glioblastoma is the most aggressive form of brain tumor, accounting for the highest mortality
and morbidity rates. Current treatment for patients with glioblastoma includes maximal safe …

Introduction: Glioblastoma is a type of brain cancer arises from glial cells. Glioblastoma
multiforme (GBM), a subtype of glioblastoma, is the most common and most aggressive …

High-grade gliomas are still characterized by a poor prognosis, despite recent advances in
surgical treatment. Chemotherapy is currently practiced after surgery, but its efficacy is …

Brain cancers, particularly malignant gliomas such as glioblastoma, are highly invasive and
characterized by elevated complexity, heterogeneity, and high infiltration ability. Therefore …

In spite of substantial progress made in the standard treatment and ancillary therapies that
include concurrent chemotherapy, radiotherapy, and surgery, malignant brain tumors …

Simple Summary As one of the most lethal human cancers, glioblastoma treatment is a real
challenge because of several resistance mechanisms, including limited drug entry into the …