Neuropathic pain (NP) is a debilitating condition stemming from damage to the
somatosensory system frequently caused by nerve injuries or lesions. While existing …

Peripheral nerve blockade is an important perioperative intervention for pain management.
However, this management always results in a limited analgesia effect due to the rapid …

Postoperative pain is a major concern for most of the surgical patients, and an inadequate
postoperative pain control may cause a series of complications. With an effective pain …

Considering the astonishing prevalence of localized pain affecting billions of patients
worldwide, the development of advanced analgesic formulations or delivery systems to …

Local anesthetics are commonly used for the management of intraoperative and
postoperative acute and chronic pain caused by small invasive procedures. However, their …

Postoperative pain is a complex physiological response to disease and tissue injury.
Moderate-to-severe pain typically occurs within 48 h after surgery. Amino amide local …

Local anesthetics are important for the treatment of postoperative pain. Since a single
injection of the solution of a drug such as bupivacaine (BUP) works only for a few hours, it is …

Developing novel biomaterials that deliver multiple regulatory signals is crucial to tissue
regeneration by creating an ideal regenerative microenvironment. The purpose of the study …

Thermosensitive chitosan/β-glycerophosphate (CS/BGP) systems have been developed as
injectable hydrogels. However, the hydrogels exhibited poor mechanical properties due to …

To treat neuropathic pain, dexamethasone (DEX, an anti-inflammatory agent) and
ropivacaine (RVC, a local anesthetic) are injected into the epidural space of the patient's …