The respiratory system is the primary route of infection for many contagious pathogens.
Mucociliary clearance of inhaled pathogens is an important innate defence mechanism …

Multiciliated cells maintain the flow of pulmonary mucus through the coordinated beating of
cilia (1). When mucociliary clearance is impaired, pathogens and environmental …

INTRODUCTION Changes in the size and proportion of limbs and other structures have
played a key role in the evolution of species. One common class of limb modification is …

Cilia (flagella) are important eukaryotic organelles, present in the Last Eukaryotic Common
Ancestor, and are involved in cell motility and integration of extracellular signals. Ciliary …

Malfunctions of motile cilia cause a variety of developmental defects and diseases in
humans and animal model organisms. Defects include impaired mucociliary clearance of …

Cilia are fundamental organelles of eukaryotes with diverse functions spanning from cell
motility to sensory perception. A new study presenting genomes from parasitic horsehair …

SNPs in the FAM13A locus are amongst the most commonly reported risk alleles associated
with chronic obstructive pulmonary disease (COPD) and other respiratory diseases …

Predicting phenotype from genotype represents the epitome of biological questions.
Comparative genomics of appropriate model organisms holds the promise of making it …

Intraflagellar transport (IFT) is a highly conserved mechanism for motor-driven transport of
cargo within cilia, but how this cargo is selectively transported to cilia and across the …

The ciliate phylum is a group of protists noted for their unusual membrane trafficking system
and apparent environmental ubiquity; as highly successful microbial predators, they are …