Mixed infection by Clostridium difficile in an in vitro model of the human gut

SD Baines, GS Crowther, SL Todhunter… - Journal of …, 2013 - academic.oup.com
Objectives Clostridium difficile infection (CDI) is still a major clinical challenge. Previous
studies have demonstrated multiple distinct C. difficile strains in the faeces of patients with …

Recurrence of dual-strain Clostridium difficile infection in an in vitro human gut model

GS Crowther, CH Chilton, SL Todhunter… - Journal of …, 2015 - academic.oup.com
Background Clostridium difficile infection (CDI) is still a major challenge to healthcare
facilities. The detection of multiple C. difficile strains has been reported in some patient …

Effects of piperacillin/tazobactam on Clostridium difficile growth and toxin production in a human gut model

SD Baines, J Freeman, MH Wilcox - Journal of Antimicrobial …, 2005 - academic.oup.com
Objectives: Clostridium difficile infection (CDI) is a major cause of morbidity in the
nosocomial environment. Antimicrobial agents such as the third-generation cephalosporins …

[HTML][HTML] Clinical impact of Clostridium difficile colonization

YP Hung, JC Lee, HJ Lin, HC Liu, YH Wu… - Journal of Microbiology …, 2015 - Elsevier
Clostridium difficile can cause antibiotic-associated diarrhea in hospitalized patients.
Asymptomatic colonization by C. difficile is common during the neonatal period and early …

[HTML][HTML] A Review of Mixed Strain Clostridium difficile Colonization and Infection

P Dayananda, MH Wilcox - Frontiers in microbiology, 2019 - frontiersin.org
Given that Clostridium difficile is not part of the normal human microbiota, if multiple strains
are to accumulate in the colon implies successive exposure events and/or persistent …

Effects of Exposure of Clostridium difficile PCR Ribotypes 027 and 001 to Fluoroquinolones in a Human Gut Model

K Saxton, SD Baines, J Freeman… - Antimicrobial agents …, 2009 - Am Soc Microbiol
The incidence of Clostridium difficile infection is increasing, with reports implicating
fluoroquinolone use. A three-stage chemostat gut model was used to study the effects of …

Clostridium difficile colonization in healthy adults: transient colonization and correlation with enterococcal colonization

E Ozaki, H Kato, H Kita, T Karasawa… - Journal of medical …, 2004 - microbiologyresearch.org
The aim of the present study was to investigate the colonization status of Clostridium difficile
in healthy individuals. In total, 139 healthy adults from two study groups were examined at …

Quantification of Clostridium difficile in antibiotic-associated-diarrhea patients

P Naaber, J Štšepetova, I Smidt, M Rätsep… - Journal of clinical …, 2011 - Am Soc Microbiol
Comparing culture-and non-culture-based methods for quantifying Clostridium difficile in
antibiotic-associated-diarrhea patients, we found that the real-time PCR method correlated …

Effect of metronidazole on growth and toxin production by epidemic Clostridium difficile PCR ribotypes 001 and 027 in a human gut model

J Freeman, SD Baines, K Saxton… - Journal of Antimicrobial …, 2007 - academic.oup.com
Objectives We compared the behaviour of Clostridium difficile PCR ribotypes 001 and 027 in
a human gut model, and compared the responses to metronidazole exposure. Methods …

Clostridium difficile infection: monoclonal or polyclonal genesis?

M Hell, M Permoser, G Chmelizek, JM Kern, M Maass… - Infection, 2011 - Springer
Clostridium difficile is considered to be a leading cause of hospital-acquired diarrhea. C.
difficile (CDI) infection shows a high rate of recurrence. There would have to be a …