Ethnopharmacological relevance Paeoniflorin (PF) was found to exhibit renal protection
from diabetic kidney disease (DKD) in previous trials, but its specific mechanism remains to …

Necroptosis was elevated in both tubulointerstitial and glomerular renal tissue in patients
with diabetic kidney disease (DKD), and was most pronounced on glomerulus in the stage …

Paeoniflorin (PF) is the primary component of total glucosides of paeony (TGP). It exerts
multiple effects, including immunoregulatory and anti-inflammatory effects. Our previous …

Paeoniflorin is the main bioactive components of the root of P. lactiflora Pall., and has been
widely used as an anti-inflammation and immunomodulatory agent. However, the effect and …

Radix astragali, a medicinal material for tonifying Chinese Qi, has widely been used for the
treatment of Kidney disease in China and East Asia, especially in reducing the apoptosis of …

Glomerular mesangial cell plays a vital role in diabetic nephropathy (DN). Recent research
has demonstrated that autophagy involved in the development of DN. Paeoniflorin (PF), a …

Diabetic nephropathy (DN) is one of the primary complications of diabetes. Fisetin is a
flavonoid polyphenol that is present in several vegetables and fruits. The present study …

Background Macrophages M1 polarization involved in the process of renal inflammatory
injury, is a well-established hallmark of chronic kidney disease (CKD). Paeoniflorin (PF), a …

Introduction Renal podocyte injury, apoptosis and autophagy are involved in the occurrence
and development of diabetic nephropathy (DN). Kaempferol (KPF) has the promotion of …

Diabetic nephropathy (DN) is a common pathological feature in patients with diabetes and
the leading cause of end-stage renal disease. Although several pharmacological agents …