[HTML][HTML] Improving adenine and dual base editors through introduction of TadA-8e and Rad51DBD
N Xue, X Liu, D Zhang, Y Wu, Y Zhong, J Wang… - Nature …, 2023 - nature.com
Base editors, including dual base editors, are innovative techniques for efficient base
conversions in genomic DNA. However, the low efficiency of A-to-G base conversion at …
conversions in genomic DNA. However, the low efficiency of A-to-G base conversion at …
[HTML][HTML] A split and inducible adenine base editor for precise in vivo base editing
DNA base editors use deaminases fused to a programmable DNA-binding protein for
targeted nucleotide conversion. However, the most widely used TadA deaminases lack post …
targeted nucleotide conversion. However, the most widely used TadA deaminases lack post …
Adenine base editor engineering reduces editing of bystander cytosines
YK Jeong, SH Lee, GH Hwang, SA Hong, S Park… - Nature …, 2021 - nature.com
Adenine base editors (ABEs) catalyze specific A-to-G conversions at genomic sites of
interest. However, ABEs also induce cytosine deamination at the target site. To reduce the …
interest. However, ABEs also induce cytosine deamination at the target site. To reduce the …
[HTML][HTML] Human cell based directed evolution of adenine base editors with improved efficiency
J Fu, Q Li, X Liu, T Tu, X Lv, X Yin, J Lv, Z Song… - Nature …, 2021 - nature.com
Adenine base editors (ABE) are genome-editing tools that have been harnessed to
introduce precise A• T to G• C conversion. However, the low activity of ABE at certain sites …
introduce precise A• T to G• C conversion. However, the low activity of ABE at certain sites …
An adenine base editor variant expands context compatibility
Adenine base editors (ABEs) are precise gene-editing agents that convert A: T pairs into G:
C through a deoxyinosine intermediate. Existing ABEs function most effectively when the …
C through a deoxyinosine intermediate. Existing ABEs function most effectively when the …
Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants
L Yang, X Zhang, L Wang, S Yin, B Zhu, L Xie… - Protein & …, 2018 - academic.oup.com
The clustered regularly interspaced short palindromic repeat (CRISPR) system has been
widely adapted to genome editing to either introduce or correct genetic mutations (Wang et …
widely adapted to genome editing to either introduce or correct genetic mutations (Wang et …
[HTML][HTML] TadA orthologs enable both cytosine and adenine editing of base editors
S Zhang, B Yuan, J Cao, L Song, J Chen, J Qiu… - Nature …, 2023 - nature.com
Cytidine and adenosine deaminases are required for cytosine and adenine editing of base
editors respectively, and no single deaminase could enable concurrent and comparable …
editors respectively, and no single deaminase could enable concurrent and comparable …
Engineering a precise adenine base editor with minimal bystander editing
Adenine base editors (ABEs) catalyze A-to-G transitions showing broad applications, but
their bystander mutations and off-target editing effects raise safety concerns. Through …
their bystander mutations and off-target editing effects raise safety concerns. Through …
[HTML][HTML] High performance TadA-8e derived cytosine and dual base editors with undetectable off-target effects in plants
Cytosine base editors (CBEs) and adenine base editors (ABEs) enable precise C-to-T and A-
to-G edits. Recently, ABE8e, derived from TadA-8e, enhances A-to-G edits in mammalian …
to-G edits. Recently, ABE8e, derived from TadA-8e, enhances A-to-G edits in mammalian …
Dual base editor catalyzes both cytosine and adenine base conversions in human cells
X Zhang, B Zhu, L Chen, L Xie, W Yu, Y Wang… - Nature …, 2020 - nature.com
Although base editors are useful tools for precise genome editing, current base editors can
only convert either adenines or cytosines. We developed a dual adenine and cytosine base …
only convert either adenines or cytosines. We developed a dual adenine and cytosine base …