Base editors, including dual base editors, are innovative techniques for efficient base
conversions in genomic DNA. However, the low efficiency of A-to-G base conversion at …

DNA base editors use deaminases fused to a programmable DNA-binding protein for
targeted nucleotide conversion. However, the most widely used TadA deaminases lack post …

Adenine base editors (ABEs) catalyze specific A-to-G conversions at genomic sites of
interest. However, ABEs also induce cytosine deamination at the target site. To reduce the …

Adenine base editors (ABE) are genome-editing tools that have been harnessed to
introduce precise A• T to G• C conversion. However, the low activity of ABE at certain sites …

Adenine base editors (ABEs) are precise gene-editing agents that convert A: T pairs into G:
C through a deoxyinosine intermediate. Existing ABEs function most effectively when the …

The clustered regularly interspaced short palindromic repeat (CRISPR) system has been
widely adapted to genome editing to either introduce or correct genetic mutations (Wang et …

Cytidine and adenosine deaminases are required for cytosine and adenine editing of base
editors respectively, and no single deaminase could enable concurrent and comparable …

Adenine base editors (ABEs) catalyze A-to-G transitions showing broad applications, but
their bystander mutations and off-target editing effects raise safety concerns. Through …

Cytosine base editors (CBEs) and adenine base editors (ABEs) enable precise C-to-T and A-
to-G edits. Recently, ABE8e, derived from TadA-8e, enhances A-to-G edits in mammalian …

Although base editors are useful tools for precise genome editing, current base editors can
only convert either adenines or cytosines. We developed a dual adenine and cytosine base …