ABSTRACT NLRP3 inflammasome mainly controls interleukin-1β (IL-1β) secretion, leading
to cell death called pyroptosis constituting a major antiviral host defense and inflammatory …

The inflammasome is a molecular platform that stimulates the activation of caspase-1 and
the processing of pro-interleukin (IL)-1β and pro-IL-18 for secretion. The NOD-like receptor …

Host innate immune system is critical for combating invading microbes including Influenza A
virus (IAV). As an important arm of the innate immunity, the NLRP3 inflammasome has been …

The inflammasome NLRP3 is activated by pathogen associated molecular patterns (PAMPs)
during infection, including RNA and proteins from influenza A virus (IAV). However, chronic …

The innate immune system provides the host with both a dynamic barrier to prevent infection
and a means to which rapid anti-microbial responses can be mounted. The inflammasome …

The severity of influenza A virus (IAV) infection can range from asymptotic to mild to severe.
Infections, such as those seen following outbreaks of avian IAV, are associated with …

The NLRP3 inflammasome constitutes a major antiviral host defense mechanism during
influenza virus infection. Inflammasome assembly in virus-infected cells facilitates …

The inflammasome represents a molecular platform for innate immune regulation and
controls proinflammatory cytokine production. The NLRP3 inflammasome is comprised of …

Infection with seasonal as well as highly pathogenic avian influenza A virus (IAV) causes
significant morbidity and mortality worldwide. As a major virulence factor, PB1-F2 protein of …

Hyperinflammatory responses including the production of NLRP3‐dependent interleukin (IL)‐
1β is a characteristic feature of severe and fatal influenza A virus (IAV) infections. The …