Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

Numerous supramolecular protein assemblies had been demonstrated to have either
physiological or pathological activities. The most significant case of disease-associated self …

Self-assembled peptide and protein amyloid nanostructures have traditionally been
considered only as pathological aggregates implicated in human neurodegenerative …

Abnormal protein assembly causes multiple devastating disorders in the central nervous
system (CNS), such as Alzheimer's, Parkinson's, Huntington's, and prion diseases. Due to …

Many neurodegenerative disorders, including Alzheimer's, Parkinson's and the prion
diseases, are characterized by a conformational conversion of normally soluble proteins or …

Oligomeric intermediates are non-fibrillar polypeptide assemblies that occur during amyloid
fibril formation and that are thought to underlie the aetiology of amyloid diseases, such as …

Amyloids are filamentous protein deposits ranging in size from nanometres to microns and
composed of aggregated peptide β-sheets formed from parallel or anti-parallel alignments of …

Highlights•A range of functionally and structurally unrelated proteins form amyloid.•Toxic
intermediates remain elusive, making their targeting a significant challenge.•Design and …

Protein and peptides are converted from their soluble forms into highly ordered fibrillar
aggregates under various conditions inside the cell. Such transitions confer diverse …

The formation of amyloid fibrils is associated with various human medical disorders of
unrelated origin. Recent research indicates that self‐assembled amyloid fibrils are also …