Spatially selective stimulation of the pig vagus nerve to modulate target effect versus side effect
Electrical stimulation of the cervical vagus nerve using implanted electrodes (VNS) is FDA-
approved for the treatment of drug-resistant epilepsy, treatment-resistant depression, and …
approved for the treatment of drug-resistant epilepsy, treatment-resistant depression, and …
Hydrogel-based electrodes for selective cervical vagus nerve stimulation
CC Horn, M Forssell, M Sciullo, JE Harms… - Journal of Neural …, 2021 - iopscience.iop.org
Objective. Electrical vagus nerve stimulation (VNS) has the potential to treat a wide variety of
diseases by modulating afferent and efferent communication to the heart, lungs, esophagus …
diseases by modulating afferent and efferent communication to the heart, lungs, esophagus …
Vagus nerve stimulation using an endovascular electrode array
EN Nicolai, JA Larco, SI Madhani… - Journal of neural …, 2023 - iopscience.iop.org
Objective. Vagus nerve stimulation (VNS), which involves a surgical procedure to place
electrodes directly on the vagus nerve (VN), is approved clinically for the treatment of …
electrodes directly on the vagus nerve (VN), is approved clinically for the treatment of …
Validated computational models predict vagus nerve stimulation thresholds in preclinical animals and humans
Objective. We demonstrated how automated simulations to characterize electrical nerve
thresholds, a recently published open-source software for modeling stimulation of peripheral …
thresholds, a recently published open-source software for modeling stimulation of peripheral …
Model-based geometrical optimisation and in vivo validation of a spatially selective multielectrode cuff array for vagus nerve neuromodulation
Background Neuromodulation by electrical stimulation of the human cervical vagus nerve
may be limited by adverse side effects due to stimulation of off-target organs. It may be …
may be limited by adverse side effects due to stimulation of off-target organs. It may be …
Using neural biomarkers to personalize dosing of vagus nerve stimulation
A Berthon, L Wernisch, M Stoukidi, M Thornton… - Bioelectronic …, 2024 - Springer
Background Vagus nerve stimulation (VNS) is an established therapy for treating a variety of
chronic diseases, such as epilepsy, depression, obesity, and for stroke rehabilitation …
chronic diseases, such as epilepsy, depression, obesity, and for stroke rehabilitation …
Sources of off-target effects of vagus nerve stimulation using the helical clinical lead in domestic pigs
EN Nicolai, ML Settell, BE Knudsen… - Journal of neural …, 2020 - iopscience.iop.org
Objective Clinical data suggest that efficacious vagus nerve stimulation (VNS) is limited by
side effects such as cough and dyspnea that have stimulation thresholds lower than those …
side effects such as cough and dyspnea that have stimulation thresholds lower than those …
Measuring and modeling the effects of vagus nerve stimulation on heart rate and laryngeal muscles
Background Reduced heart rate (HR) during vagus nerve stimulation (VNS) is associated
with therapy for heart failure, but stimulation frequency and amplitude are limited by patient …
with therapy for heart failure, but stimulation frequency and amplitude are limited by patient …
Modulation of heart rate by temporally patterned vagus nerve stimulation in the anesthetized dog
PB Yoo, H Liu, JG Hincapie, SB Ruble… - Physiological …, 2016 - Wiley Online Library
Despite current knowledge of the myriad physiological effects of vagus nerve stimulation
(VNS) in various mammalian species (including humans), the impact of varying stimulation …
(VNS) in various mammalian species (including humans), the impact of varying stimulation …
Electrophysiological responses from vagus nerve stimulation in rats
L Mollet, R Raedt, J Delbeke, R El Tahry… - … journal of neural …, 2013 - World Scientific
The mechanism of action of vagus nerve stimulation (VNS) for pharmacoresistant epilepsy is
unknown and the therapeutic outcome is highly variable. We investigated stimulation …
unknown and the therapeutic outcome is highly variable. We investigated stimulation …