Spatially selective stimulation of the pig vagus nerve to modulate target effect versus side effect

SL Blanz, ED Musselman, ML Settell… - Journal of neural …, 2023 - iopscience.iop.org
Electrical stimulation of the cervical vagus nerve using implanted electrodes (VNS) is FDA-
approved for the treatment of drug-resistant epilepsy, treatment-resistant depression, and …

Hydrogel-based electrodes for selective cervical vagus nerve stimulation

CC Horn, M Forssell, M Sciullo, JE Harms… - Journal of Neural …, 2021 - iopscience.iop.org
Objective. Electrical vagus nerve stimulation (VNS) has the potential to treat a wide variety of
diseases by modulating afferent and efferent communication to the heart, lungs, esophagus …

Vagus nerve stimulation using an endovascular electrode array

EN Nicolai, JA Larco, SI Madhani… - Journal of neural …, 2023 - iopscience.iop.org
Objective. Vagus nerve stimulation (VNS), which involves a surgical procedure to place
electrodes directly on the vagus nerve (VN), is approved clinically for the treatment of …

Validated computational models predict vagus nerve stimulation thresholds in preclinical animals and humans

ED Musselman, NA Pelot, WM Grill - Journal of Neural …, 2023 - iopscience.iop.org
Objective. We demonstrated how automated simulations to characterize electrical nerve
thresholds, a recently published open-source software for modeling stimulation of peripheral …

Model-based geometrical optimisation and in vivo validation of a spatially selective multielectrode cuff array for vagus nerve neuromodulation

K Aristovich, M Donega, C Fjordbakk, I Tarotin… - Journal of neuroscience …, 2021 - Elsevier
Background Neuromodulation by electrical stimulation of the human cervical vagus nerve
may be limited by adverse side effects due to stimulation of off-target organs. It may be …

Using neural biomarkers to personalize dosing of vagus nerve stimulation

A Berthon, L Wernisch, M Stoukidi, M Thornton… - Bioelectronic …, 2024 - Springer
Background Vagus nerve stimulation (VNS) is an established therapy for treating a variety of
chronic diseases, such as epilepsy, depression, obesity, and for stroke rehabilitation …

Sources of off-target effects of vagus nerve stimulation using the helical clinical lead in domestic pigs

EN Nicolai, ML Settell, BE Knudsen… - Journal of neural …, 2020 - iopscience.iop.org
Objective Clinical data suggest that efficacious vagus nerve stimulation (VNS) is limited by
side effects such as cough and dyspnea that have stimulation thresholds lower than those …

Measuring and modeling the effects of vagus nerve stimulation on heart rate and laryngeal muscles

WJ Huffman, ED Musselman, NA Pelot, WM Grill - Bioelectronic Medicine, 2023 - Springer
Background Reduced heart rate (HR) during vagus nerve stimulation (VNS) is associated
with therapy for heart failure, but stimulation frequency and amplitude are limited by patient …

Modulation of heart rate by temporally patterned vagus nerve stimulation in the anesthetized dog

PB Yoo, H Liu, JG Hincapie, SB Ruble… - Physiological …, 2016 - Wiley Online Library
Despite current knowledge of the myriad physiological effects of vagus nerve stimulation
(VNS) in various mammalian species (including humans), the impact of varying stimulation …

Electrophysiological responses from vagus nerve stimulation in rats

L Mollet, R Raedt, J Delbeke, R El Tahry… - … journal of neural …, 2013 - World Scientific
The mechanism of action of vagus nerve stimulation (VNS) for pharmacoresistant epilepsy is
unknown and the therapeutic outcome is highly variable. We investigated stimulation …