Population medical genetics aims at translating clinically relevant findings from recent
studies of large cohorts into healthcare for individuals. Genetic counseling concerning …

Studies of genetic contributions to risk can be family-based, such as the case-parents
design, or population-based, such as the case-control design. Both provide powerful …

METHODS Study cohort The village populations of three neighbouring islands in the eastern
Adriatic, part of Middle Dalmatia, Croatia (Brac, Hvar, and Korcula, see fig 1), represent well …

Background Genetic counseling has been an important tool for evaluating and
communicating disease susceptibility for decades, and it has been applied to predict risks …

We investigate the effects of consanguinity and population substructure on genetic health
using the UK Asian population as an example. We review and expand upon previous …

We propose a method, the maximum identity length contrast (MILC) statistic, to locate
genetic risk factors for complex diseases in founder populations. The MILC approach …

Background The offspring of consanguineous relations have an increased risk of
congenital/genetic disorders and early mortality. Consanguineous couples and their …

Objectives Consanguinity is common in Tunisia. However, little information exists on its
impact on recessive disorders. In this study, we evaluate the impact of consanguineous …

In the area of genetic epidemiology, genetic risk predictive modeling is becoming an
important area of translational success. As an increasing number of genetic variants are …

Motivation: Family-based designs are regaining popularity for genomic sequencing studies
because they provide a way to test cosegregation with disease of variants that are too rare in …