[HTML][HTML] LINE-1 retrotransposons contribute to mouse PV interneuron development

GO Bodea, JM Botto, ME Ferreiro… - Nature …, 2024 - nature.com
Retrotransposons are mobile DNA sequences duplicated via transcription and reverse
transcription of an RNA intermediate. Cis-regulatory elements encoded by retrotransposons …

L1 retrotransposition in neurons is modulated by MeCP2

AR Muotri, MCN Marchetto, NG Coufal, R Oefner… - Nature, 2010 - nature.com
Long interspersed nuclear elements-1 (LINE-1 or L1s) are abundant retrotransposons that
comprise approximately 20% of mammalian genomes,,. Active L1 retrotransposons can …

Neuronal genome plasticity: retrotransposons, environment and disease

MJHC Kempen, GO Bodea, GJ Faulkner - Human retrotransposons in …, 2017 - Springer
The neuronal genome has long been considered as a stably persisting entity interpreted as
the foundation of neurobiology. Over the past decade, it has become increasingly clear that …

[PDF][PDF] LINE-1: creators of neuronal diversity

CA Thomas, AR Muotri - Frontiers in Bioscience-Elite, 2012 - article.imrpress.com
Long interspersed nucleotide element 1 (L1) is a family of non-LTR retrotransposons that
can replicate and reintegrate into the host genome. L1s have considerably influenced …

Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia

X Zhu, B Zhou, R Pattni, K Gleason, C Tan… - Nature …, 2021 - nature.com
Retrotransposons can cause somatic genome variation in the human nervous system, which
is hypothesized to have relevance to brain development and neuropsychiatric disease …

L1 retrotransposons and somatic mosaicism in the brain

SR Richardson, S Morell… - Annual review of genetics, 2014 - annualreviews.org
Long interspersed element 1 (LINE-1 or L1) retrotransposons have generated one-third of
the human genome, and their ongoing mobility is a source of inter-and intraindividual …

L1 retrotransposition in neural progenitor cells

AR Muotri - Transposons and Retrotransposons: Methods and …, 2016 - Springer
Long interspersed nucleotide element 1 (LINE-1 or L1) is a family of non-LTR
retrotransposons that can replicate and reintegrate into the host genome. L1s have …

LINE-1 retrotransposons: mediators of somatic variation in neuronal genomes?

T Singer, MJ McConnell, MCN Marchetto… - Trends in …, 2010 - cell.com
LINE-1 (L1) elements are retrotransposons that insert extra copies of themselves throughout
the genome using a 'copy and paste'mechanism. L1s comprise nearly∼ 20% of the human …

Somatic retrotransposition in the developing rhesus macaque brain

V Billon, FJ Sanchez-Luque, J Rasmussen… - Genome …, 2022 - genome.cshlp.org
The retrotransposon LINE-1 (L1) is central to the recent evolutionary history of the human
genome and continues to drive genetic diversity and germline pathogenesis. However, the …

Somatic retrotransposition alters the genetic landscape of the human brain

JK Baillie, MW Barnett, KR Upton, DJ Gerhardt… - Nature, 2011 - nature.com
Retrotransposons are mobile genetic elements that use a germline 'copy-and-
paste'mechanism to spread throughout metazoan genomes. At least 50 per cent of the …