Evaluation of genetic instability, oxidative stress, and metabolism-related gene polymorphisms in workers exposed to waste anesthetic gases

MAP Silva, DBS Figueiredo, JR Lara… - … Science and Pollution …, 2023 - Springer
Professionals who work in operating rooms (ORs) may be exposed daily to waste anesthetic
gases (WAGs) due to the use of inhalational anesthetics. Considering the controversial …

Modulation of gene expression and influence of gene polymorphisms related to genotoxicity and redox status on occupational exposure to inhaled anesthetics

MAP Silva, DBS Figueiredo, LR de Carvalho… - International Journal of …, 2024 - Elsevier
Operating room professionals are constantly exposed to waste anesthetic gases (WAGs)
due to the extensive use of inhalational anesthetics (NIOSH-National Institute for …

Oxidative stress, DNA damage, inflammation and gene expression in occupationally exposed university hospital anesthesia providers

KM Souza, I De Vivo, CY Chen… - Environmental and …, 2021 - Wiley Online Library
Considering the importance and lack of data of toxicogenomic approaches on occupational
exposure to anesthetics, we evaluated possible associations between waste anesthetic …

High concentrations of waste anesthetic gases induce genetic damage and inflammation in physicians exposed for three years: A cross‐sectional study

MG Braz, LIM Carvalho, CYO Chen, JB Blumberg… - Indoor …, 2020 - Wiley Online Library
This cross‐sectional study analyzed the impact of occupational waste anesthetic gases on
genetic material, oxidative stress, and inflammation status in young physicians exposed to …

High anesthetic exposure leads to oxidative damage and gene expression changes in physicians during medical residency: a cohort study

AG Aun, DC Damasceno, YK Sinzato… - … Science and Pollution …, 2023 - Springer
Abstract Evaluation of the possible toxic effects of occupational exposure to anesthetics is of
great importance, and the literature is limited in assessing the possible association between …

Genetic damage of operating and recovery room personnel occupationally exposed to waste anaesthetic gases

G Çakmak, D Eraydın, A Berkkan… - Human & …, 2019 - journals.sagepub.com
Occupational exposure to the waste anaesthetic gases (WAGs) is a crucial problem for
healthcare personnel. Cancer is among the potential long-term adverse effects of WAGs …

Association between genotoxic properties of inhalation anesthetics and oxidative stress biomarkers

M Neghab, F Kargar-Shouroki… - Toxicology and …, 2020 - journals.sagepub.com
Exposure to inhalation anesthetics (IAs) has been associated with DNA damage as reflected
in the increased frequency of micronuclei (MN) and chromosomal aberrations (CAs). The …

Genotoxicity of inhalational anesthetics and its relationship with the polymorphisms of GSTT1, GSTM1, and GSTP1 genes

F Kargar Shouroki, M Neghab, H Mozdarani… - … Science and Pollution …, 2019 - Springer
Due to their wide applications, concern exists regarding possible genotoxic effects of
inhalational anesthetics (IAs) among operating room personnel. This study was undertaken …

Occupational exposure to anesthetics leads to genomic instability, cytotoxicity and proliferative changes

KM Souza, LG Braz, FR Nogueira, MB Souza… - Mutation Research …, 2016 - Elsevier
Data on the genotoxic and mutagenic effects of occupational exposure to the most frequently
used volatile anesthetics are limited and controversial. The current study is the first to …

High anesthetic (isoflurane) indoor pollution is associated with genetic instability, cytotoxicity, and proliferative alterations in professionals working in a veterinary …

DBS Figueiredo, AG Aun, KM Souza… - … Science and Pollution …, 2022 - Springer
This is the first study to monitor anesthetic pollution in veterinary operating rooms (VOR) and
assess the toxicological impact of the inhalational anesthetic isoflurane (exposed group) …