Subjected to countless daily injuries, the stomach still functions as a remarkably efficient
digestive organ and microbial filter. In this Review, we follow the lead of the earliest …

The development of intestinal‐type gastric cancer is preceded by the emergence of
metaplastic cell lineages in the gastric mucosa. In particular, intestinal metaplasia and …

The mucosa of the body of the stomach (ie, the gastric corpus) uses 2 overlapping, depth-
dependent mechanisms to respond to injury. Superficial injury heals via surface cells with …

Gastric carcinogenesis involves the loss of parietal cells (oxyntic atrophy) and subsequent
replacement of the normal gastric lineages with metaplastic cells. In humans, two …

Gastric cancer in humans arises in the setting of oxyntic atrophy (parietal cell loss) and
attendant hyperplastic and metaplastic lineage changes within the gastric mucosa …

During human gastric carcinogenesis, intestinal metaplasia is frequently seen in the atrophic
stomach. In mice, a distinct type of metaplasia known as spasmolytic polypeptide-expressing …

Spasmolytic polypeptide-expressing metaplasia (SPEM) develops in patients with chronic
atrophic gastritis due to infection with Helicobacter pylori; it might be a precursor to intestinal …

The development of intestinal-type gastric cancer is preceded by loss of parietal cells
(oxyntic atrophy) and the induction of metaplastic cell lineages in the gastric mucosa. For …

It has long been known that differentiated cells can switch fates, especially in vitro, but only
recently has there been a critical mass of publications describing the mechanisms adult …

Gastric cancer is the second leading cause of cancer-related death worldwide, but the
details of gastric carcinogenesis remain unclear. In humans, two preneoplastic metaplasias …