The biological membrane covers all living cells and provides an effective barrier against the
passage of biologically important water-soluble solutes. This natural passage barrier is …

The biological membrane is an efficient barrier against water-soluble substances. Solute
transporters circumvent this membrane barrier by transporting water-soluble solutes across …

The major facilitator superfamily, discovered in the late 1980s, is currently composed of
thousands of characterized integral membrane transporters. These transport systems of the …

Transport of solutes across biological membranes is essential for cellular life. This process is
mediated by membrane transport proteins which move nutrients, waste products, certain …

Simple Summary A phospholipid membrane covers all living cells, forming an impenetrable
barrier circumvented by solute transporters in the cell membrane. These proteins comprise …

Pathogenic microorganisms that are multidrug-resistant can pose severe clinical and public
health concerns. In particular, bacterial multidrug efflux transporters of the major facilitator …

Bacteria carry a battery of multidrug transporters, which belong to six families of transporters.
Members of at least three families the ATP-Binding Cassette superfamily, the Major …

The major facilitator superfamily (MFS) of proteins constitutes a large group of related solute
transporters found across all known living taxa of organisms. The transporters of the MFS …

Multidrug transporters are membrane proteins that expel a wide spectrum of cytotoxic
compounds from the cell. Through this function, they render cells resistant to multiple drugs …

Many transport proteins of bacteria and eukaryotes are thought to possess a common
structural motif of 12 transmembrane-spanning α-helical segments. In this report we use …