Autophagy is a highly conserved intracellular degradation process that plays a crucial role in
cell survival and stress reactions as well as in cancer development and metastasis …

FoxO proteins are important regulators in cellular metabolism and are recognized to be
nodes in multiple signaling pathways, most notably those involving PI3K/AKT and mTOR …

Autophagy controls cellular remodeling and quality control. Dysregulated autophagy has
been implicated in several human diseases including obesity, diabetes, cardiovascular …

Although Beclin 1 and mTOR are considered to be the main molecules to modulate the
autophagic process, searching for other autophagy-regulating molecules is still an ongoing …

Proliferation, differentiation and apoptosis are tightly regulated by extracellular stimuli
including hormones, growth factors and cytokines. A balance between these processes is a …

Background/Aims: Previous studies have shown that FOXO3, a member of the forkhead box
O (FOXO) family, regulates autophagy in various cells. To date, whether the induction of …

The PI3K-Akt-FoxO signaling pathway plays a central role in diverse physiological
processes including cellular energy storage, growth, and survival, among others. As an …

Background/Aims: Autophagy is an evolutionarily conserved catabolic mechanism to
maintain energy homeostasis and to remove damaged cellular components, which plays an …

Autophagy is characterized by the sequestration of bulk cytoplasm, including damaged
proteins and organelles, and delivery of the cargo to lysosomes for degradation. Although …

Apoptosis has been widely accepted as the primary mechanism of drug-induced cell death.
Recently, a second type of cell death pathway has been demonstrated: autophagy, also …