BRCA1-and BRCA2-associated hereditary breast and ovarian cancer (HBOC) is
characterized by an increased risk for female and male breast cancer, ovarian cancer …

Hereditary breast and ovarian cancer due to mutations in the BRCA1 and BRCA2 genes is
the most common cause of hereditary forms of both breast and ovarian cancer. The overall …

Hereditary breast and ovarian cancer (HBOC) syndrome is most commonly characterized by
deleterious germline mutations in BRCA1 and BRCA2. HBOC patients are prone to the …

Several genes associated with hereditary ovarian cancer have been discovered as a result
of the work done with next generation sequencing. It is estimated that approximately 23% of …

The cancer susceptibility genes BRCA1 and BRCA2 appear to be responsible for virtually all
hereditary breast ovarian families, and a smaller subset of hereditary site-specific breast …

PURPOSE: Data from the Breast Cancer Linkage Consortium suggest that the proportion of
familial breast and ovarian cancers linked to BRCA1 or BRCA2 may be as high as 98 …

Women with hereditary breast and ovarian cancer (HBOC) syndrome represent a unique
group who are diagnosed at a younger age and result in an increased lifetime risk for …

At least 10% of all ovarian cancers are estimated to have a hereditary background.
Hereditary breast–ovarian cancer (HBOC) due to mutations in the BRCA genes is a major …

An estimated 5 to 10% of all breast and ovarian cancer is attributable to inherited mutations
in two highly penetrant autosomal dominant susceptibility genes, BRCA1 and BRCA2 …

Individuals carrying germline mutations in one allele of the BRCA1 or BRCA2 genes are at
significantly increased risk of developing cancer. Although the increased risk of breast …