Asthma is a common disease in paediatrics and adults with a significant morbidity, mortality,
and financial burden worldwide. Asthma is now recognized as a heterogeneous disease …

Asthma is a chronic inflammatory disease of the airways that is challenging to dissect into
subgroups because of the heterogeneity present across the spectrum of the disease. Efforts …

The model of asthma as a single entity has now been replaced by a much more complex
biological network of distinct and interrelating inflammatory pathways. The term asthma is …

Introduction: Asthma, a common, non-communicable chronic disease affects over 300
million individuals worldwide. The Western world lifestyle is claimed to be responsible for …

Over time, there has been a shift in the paradigm of asthma, from a single-disease concept
toward a greater recognition of asthma as a complex, chronic disease with marked clinical …

Asthma is a common chronic disease characterized by intermittent chest symptoms, variable
airways obstruction, and bronchial hyperresponsiveness. Research performed over the past …

Each of the hallmark characteristics of asthma (inflammation, remodeling, airway
hyperreactivity) is the expression of a complex network of molecules, very diverse both …

Asthma is the most common chronic pediatric lung disease that has traditionally been
defined as a syndrome of airway inflammation characterized by clinical symptoms of cough …

Asthma is characterized by multiple immunological mechanisms (endotypes) determining
variable clinical presentations (phenotypes). The identification of endotypic mechanisms is …

Childhood asthma represents a heterogeneous challenging disease, in particular in its
severe forms. The identification of different asthma phenotypes has stimulated research in …