Dendrimer− drug conjugates for tailored intracellular drug release based on glutathione levels

RS Navath, YE Kurtoglu, B Wang, S Kannan… - Bioconjugate …, 2008 - ACS Publications
N-Acetyl-l-cysteine (NAC) is an antioxidant and anti-inflammatory agent with significant
potential in clinical applications including stroke and neuroinflammation. The drug shows …

Poly (amidoamine) dendrimer–drug conjugates with disulfide linkages for intracellular drug delivery

YE Kurtoglu, RS Navath, B Wang, S Kannan… - Biomaterials, 2009 - Elsevier
Understanding and improving drug release kinetics from dendrimer–drug conjugates are
key steps to improve their in vivo efficacy. N-Acetyl cysteine (NAC) is an anti-inflammatory …

Scalable synthesis and validation of PAMAM dendrimer‐N‐acetyl cysteine conjugate for potential translation

R Sharma, A Sharma, SP Kambhampati… - Bioengineering & …, 2018 - Wiley Online Library
Dendrimer‐N‐acetyl cysteine (D‐NAC) conjugate has shown significant promise in multiple
preclinical models of brain injury and is undergoing clinical translation. D‐NAC is a …

Anti-inflammatory and anti-oxidant activity of anionic dendrimer–N-acetyl cysteine conjugates in activated microglial cells

B Wang, RS Navath, R Romero, S Kannan… - International journal of …, 2009 - Elsevier
Dendrimers are emerging as potential intracellular drug delivery vehicles. Understanding
and improving the cellular efficacy of dendrimer–drug conjugates, can lead to significant in …

Peptide-and saccharide-conjugated dendrimers for targeted drug delivery: a concise review

J Liu, WD Gray, ME Davis, Y Luo - Interface Focus, 2012 - royalsocietypublishing.org
Dendrimers comprise a category of branched materials with diverse functions that can be
constructed with defined architectural and chemical structures. When decorated with …

Redox and pH-responsive poly (amidoamine) dendrimer–poly (ethylene glycol) conjugates with disulfide linkages for efficient intracellular drug release

W Hu, L Cheng, L Cheng, M Zheng, Q Lei, Z Hu… - Colloids and Surfaces B …, 2014 - Elsevier
Nanocarriers with low toxicity, high stability, long circulation in blood and triggered drug
release at target sites are extremely needed for cancer therapy. In this study, different molar …

Doxorubicin-conjugated PAMAM dendrimers for pH-responsive drug release and folic acid-targeted cancer therapy

M Zhang, J Zhu, Y Zheng, R Guo, S Wang, S Mignani… - Pharmaceutics, 2018 - mdpi.com
We present here the development of multifunctional doxorubicin (DOX)-conjugated poly
(amidoamine)(PAMAM) dendrimers as a unique platform for pH-responsive drug release …

N-acetyl-d-glucosamine-conjugated PAMAM dendrimers as dual receptor-targeting nanocarriers for anticancer drug delivery

D Pooja, TS Reddy, H Kulhari, A Kadari… - European Journal of …, 2020 - Elsevier
Abstract N-acetyl-d-glucosamine-labelled dendrimers (NAG-Dend) were synthesized for the
targeted delivery of camptothecin (CPT) to A549 human lung adenocarcinoma cells, which …

Synthesis, cellular transport, and activity of polyamidoamine dendrimer− methylprednisolone conjugates

J Khandare, P Kolhe, O Pillai, S Kannan… - Bioconjugate …, 2005 - ACS Publications
Dendrimers have emerged as promising multifunctional nanomaterials for drug delivery due
to their well-defined size and tailorability. We compare two schemes to obtain …

Activity of dendrimer− methotrexate conjugates on methotrexate-sensitive and-resistant cell lines

S Gurdag, J Khandare, S Stapels… - Bioconjugate …, 2006 - ACS Publications
Dendritic nanostructures can play a key role in drug delivery, due to the high density and
variety of surface functional groups that can facilitate and modulate the delivery process. We …