Dendrimer− drug conjugates for tailored intracellular drug release based on glutathione levels
RS Navath, YE Kurtoglu, B Wang, S Kannan… - Bioconjugate …, 2008 - ACS Publications
N-Acetyl-l-cysteine (NAC) is an antioxidant and anti-inflammatory agent with significant
potential in clinical applications including stroke and neuroinflammation. The drug shows …
potential in clinical applications including stroke and neuroinflammation. The drug shows …
Poly (amidoamine) dendrimer–drug conjugates with disulfide linkages for intracellular drug delivery
YE Kurtoglu, RS Navath, B Wang, S Kannan… - Biomaterials, 2009 - Elsevier
Understanding and improving drug release kinetics from dendrimer–drug conjugates are
key steps to improve their in vivo efficacy. N-Acetyl cysteine (NAC) is an anti-inflammatory …
key steps to improve their in vivo efficacy. N-Acetyl cysteine (NAC) is an anti-inflammatory …
Scalable synthesis and validation of PAMAM dendrimer‐N‐acetyl cysteine conjugate for potential translation
Dendrimer‐N‐acetyl cysteine (D‐NAC) conjugate has shown significant promise in multiple
preclinical models of brain injury and is undergoing clinical translation. D‐NAC is a …
preclinical models of brain injury and is undergoing clinical translation. D‐NAC is a …
Anti-inflammatory and anti-oxidant activity of anionic dendrimer–N-acetyl cysteine conjugates in activated microglial cells
B Wang, RS Navath, R Romero, S Kannan… - International journal of …, 2009 - Elsevier
Dendrimers are emerging as potential intracellular drug delivery vehicles. Understanding
and improving the cellular efficacy of dendrimer–drug conjugates, can lead to significant in …
and improving the cellular efficacy of dendrimer–drug conjugates, can lead to significant in …
Peptide-and saccharide-conjugated dendrimers for targeted drug delivery: a concise review
Dendrimers comprise a category of branched materials with diverse functions that can be
constructed with defined architectural and chemical structures. When decorated with …
constructed with defined architectural and chemical structures. When decorated with …
Redox and pH-responsive poly (amidoamine) dendrimer–poly (ethylene glycol) conjugates with disulfide linkages for efficient intracellular drug release
W Hu, L Cheng, L Cheng, M Zheng, Q Lei, Z Hu… - Colloids and Surfaces B …, 2014 - Elsevier
Nanocarriers with low toxicity, high stability, long circulation in blood and triggered drug
release at target sites are extremely needed for cancer therapy. In this study, different molar …
release at target sites are extremely needed for cancer therapy. In this study, different molar …
Doxorubicin-conjugated PAMAM dendrimers for pH-responsive drug release and folic acid-targeted cancer therapy
We present here the development of multifunctional doxorubicin (DOX)-conjugated poly
(amidoamine)(PAMAM) dendrimers as a unique platform for pH-responsive drug release …
(amidoamine)(PAMAM) dendrimers as a unique platform for pH-responsive drug release …
N-acetyl-d-glucosamine-conjugated PAMAM dendrimers as dual receptor-targeting nanocarriers for anticancer drug delivery
Abstract N-acetyl-d-glucosamine-labelled dendrimers (NAG-Dend) were synthesized for the
targeted delivery of camptothecin (CPT) to A549 human lung adenocarcinoma cells, which …
targeted delivery of camptothecin (CPT) to A549 human lung adenocarcinoma cells, which …
Synthesis, cellular transport, and activity of polyamidoamine dendrimer− methylprednisolone conjugates
J Khandare, P Kolhe, O Pillai, S Kannan… - Bioconjugate …, 2005 - ACS Publications
Dendrimers have emerged as promising multifunctional nanomaterials for drug delivery due
to their well-defined size and tailorability. We compare two schemes to obtain …
to their well-defined size and tailorability. We compare two schemes to obtain …
Activity of dendrimer− methotrexate conjugates on methotrexate-sensitive and-resistant cell lines
S Gurdag, J Khandare, S Stapels… - Bioconjugate …, 2006 - ACS Publications
Dendritic nanostructures can play a key role in drug delivery, due to the high density and
variety of surface functional groups that can facilitate and modulate the delivery process. We …
variety of surface functional groups that can facilitate and modulate the delivery process. We …
相关搜索
- drug conjugates glutathione levels
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- polyamidoamine dendrimer cellular transport
- cellular transport methylprednisolone conjugates
- drug release ethylene glycol
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- drug release glutathione levels
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