Despite major advances in assisted reproductive technologies, infertility remains a major
societal burden, with 1 in 6 couples unable to conceive a child naturally. Mammalian …

The precise interplay of hormonal influences that governs gonadotropin hormone production
by the pituitary includes endocrine, paracrine and autocrine actions of hypothalamic …

Fertility is dependent on follicle-stimulating hormone (FSH), a product of gonadotrope cells
of the anterior pituitary gland. Hypothalamic gonadotropin-releasing hormone (GnRH) and …

Mammalian reproduction depends on the gonadotropins, follicle-stimulating hormone (FSH),
and luteinizing hormone, which are secreted by pituitary gonadotrope cells. The zinc-finger …

Abstract Follicle-stimulating hormone (FSH), a major regulator of mammalian gonadal
function, is induced by gonadotropin-releasing hormone (GnRH), but it is unclear how much …

LH and FSH play crucial roles in mammalian reproduction by mediating steroidogenesis
and gametogenesis. Gonadal steroid hormones influence gonadotropin production via …

To examine in vivo, the local effects of inhibins and activins within the anterior pituitary,
independent of their endocrine effects exerted from the gonad, in mediating FSH …

Successful reproduction is essential to the survival of a species. The reproductive system
represents a highly-complex functional organization of diverse tissues and signaling …

Hypothalamic gonadotropin-releasing hormone (GnRH) acts on gonadotropes in the
anterior pituitary to stimulate gonadotropin synthesis. CGα, the common gonadotropin …

Polycystic ovary syndrome is the major cause of infertility in reproductive aged women.
Polycystic ovary syndrome is associated with high circulating levels of androgens and …