Background: Circadian rhythm disruption underlies the pathophysiology of psychiatric
disorders, especially depression. Both pharmacological and non-pharmacological strategies …

The master biological clock situated in the suprachiasmatic nuclei of the anterior
hypothalamus plays a vital role in orchestrating the circadian rhythms of multiple biological …

Recent advances in the understanding of circadian rhythms have led to an interest in the
treatment of major depressive disorder with chronobiotic agents. Many tissues have …

Objective Disturbances in circadian rhythms have been associated with major depression
and may be an underlying mechanism for the disorder. Resynchronisation of circadian …

For many patients suffering from major depressive disorder, available treatments are
unsatisfactory due to long delays before the onset of effects, low response rates, poor …

Desynchronisation of normal circadian rhythms, including the sleep–wake rhythm, is
common in major depressive disorder (MDD). The association between sleep disturbances …

The limitations of current antidepressant medications merit the exploration of alternative
agents with novel antidepressant mechanisms of action. The established clinical finding that …

Affective disorders such as major depression, bipolar disorders and seasonal affective
disorders have been described as alterations of various neuronal systems. In addition to the …

The pineal hormone melatonin is able to shift the timing of circadian rhythms, including the
sleep–wake cycle, and to promote sleep. Melatonin agonists with similar properties have …

Major depression is one of the leading causes of premature death and disability. Although
available drugs are effective, they also have substantial limitations. Recent advances in our …