Background As an inflammatory factor and oncogenic driver protein, the pleiotropic cytokine
macrophage migration inhibitory factor (MIF) plays a crucial role in the osteosarcoma …

Emerging evidence suggests that the tumour microenvironment plays a critical role in
osteosarcoma (OS) development. Thus, cytokine immunotherapy could be a novel strategy …

Current pharmacological intervention for the treatment of osteolytic bone diseases such as
osteoporosis focuses on the prevention of excessive osteoclastic bone resorption but does …

The nuclear factor kappa B (NF-κB) pathway is pivotal in controlling survival and apoptosis
of cancer cells. Macrophage migration inhibitory factor (MIF), a cytokine that regulates the …

Bone cancer is one of the most lethal malignancies and the specific causes of tumor
initiation are not well understood. B‑cell‑specific Moloney murine leukemia virus integration …

The macrophage migration‐inhibitory factor (MIF) is a pro‐inflammatory cytokine first known
for its effect on macrophage migration and activation. Recent studies have shown that MIP …

Macrophage migration inhibitory factor (MIF) has been shown to closely associate with the
malignant progression of a variety of human carcinomas. However, the role and its …

Cell migration inducing protein (CEMIP) has been linked to carcinogenesis in several types
of cancers. However, the role and mechanism of CEMIP in osteosarcoma remain unclear …

Macrophage migration inhibitory factor (MIF) is a well-described proinflammatory mediator.
MIF overexpression has been observed in many tumors and is implicated in oncogenic …

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine with proinflammatory,
proangiogenic, and protumorigenic properties. The molecular mechanisms underlying the …