Background The incubation of cue-induced drug craving in rodents provides a model of
persistent vulnerability to craving and relapse in human addicts. After prolonged withdrawal …

Cue-induced cocaine craving in rodents intensifies or “incubates” during the first months of
withdrawal from long access cocaine self-administration. This incubation phenomenon is …

Cue-induced drug craving progressively intensifies after withdrawal from self-administration
of cocaine, methamphetamine, and other drugs of abuse, a phenomenon termed incubation …

Relapse is a major problem in treating methamphetamine use disorder.“Incubation of
craving” during abstinence is a rat model for persistence of vulnerability to craving and …

Withdrawal from repeated cocaine is associated with increased synaptic and extrasynaptic
AMPA receptor (AMPAR) expression in nucleus accumbens (NAc) neurons and enhanced …

Nucleus accumbens (NAc) neurons are excited primarily by AMPA-type glutamate receptors
(AMPAR). This is required for cocaine seeking in animal models of cocaine addiction …

Extended-access cocaine self-administration results in withdrawal-dependent incubation of
cocaine craving. Rats evaluated after∼ 1 month of withdrawal from such regimens …

Although some studies report increased responsiveness of nucleus accumbens (NAc)
AMPA receptors (AMPARs) after withdrawal from repeated cocaine treatment, others report …

Cue-induced cocaine craving is a major cause of relapse in abstinent addicts. In rats, cue-
induced craving progressively intensifies (incubates) during withdrawal from extended …

This review focuses on cocaine-induced postsynaptic plasticity in the nucleus accumbens
(NAc) involving changes in AMPA receptor (AMPAR) transmission. First, fundamental …