FSH induces the development of circadian clockwork in rat granulosa cells via a gap junction protein Cx43-dependent pathway

H Chen, L Zhao, G Chu, G Kito… - American Journal …, 2013 - journals.physiology.org
The present study was designed to assess the relationship between gap junctions and the
maturation of a clock system in rat granulosa cells stimulated by follicle-stimulating hormone …

Gonadotropic regulation of circadian clockwork in rat granulosa cells

PJ He, M Hirata, N Yamauchi, S Hashimoto… - Molecular and cellular …, 2007 - Springer
The circadian clock is responsible for the generation of circadian rhythms in hormonal
secretion and metabolism. These peripheral clocks could be reset by various cues in order …

The disruption of circadian clockwork in differentiating cells from rat reproductive tissues as identified by in vitro real-time monitoring system

PJ He, M Hirata, N Yamauchi… - Journal of …, 2007 - joe.bioscientifica.com
The circadian clock, regulating hormonal secretion and metabolisms in accordance with the
environmental light–dark cycle, resides in almost all peripheral tissues as well as in the …

Contribution of FSH and triiodothyronine to the development of circadian clocks during granulosa cell maturation

G Chu, I Misawa, H Chen… - American Journal …, 2012 - journals.physiology.org
The involvement of FSH and triiodothyronine (T3) in circadian clocks was investigated using
immature granulosa cells of ovaries during the progress of cell maturation. Granulosa cells …

Alterations of circadian clockworks during differentiation and apoptosis of rat ovarian cells

G Chu, K Yoshida, S Narahara… - Chronobiology …, 2011 - Taylor & Francis
Ovarian development is related to cell proliferation, differentiation, and apoptosis of
granulosa cells and luteal cells under the control of various modulators, including follicle …

Downregulation of core clock gene Bmal1 attenuates expression of progesterone and prostaglandin biosynthesis-related genes in rat luteinizing granulosa cells

H Chen, L Zhao, M Kumazawa… - … of Physiology-Cell …, 2013 - journals.physiology.org
Ovarian circadian oscillators have been implicated in the reproductive processes of
mammals. However, there are few reports regarding the detection of ovarian clock …

Circadian Clock genes Per2 and clock regulate steroid production, cell proliferation, and luteinizing hormone receptor transcription in ovarian granulosa cells

T Shimizu, Y Hirai, C Murayama, A Miyamoto… - Biochemical and …, 2011 - Elsevier
Circadian Clock genes are associated with the estrous cycle in female animals. Treatment
with Per2 and Clock siRNAs decreased the number of granulosa cells and LHr expression …

Influence of the estrous cycle on clock gene expression in reproductive tissues: effects of fluctuating ovarian steroid hormone levels

TJ Nakamura, MT Sellix, T Kudo, N Nakao… - Steroids, 2010 - Elsevier
Circadian rhythms in physiology and behavior are known to be influenced by the estrous
cycle in female rodents. The clock genes responsible for the generation of circadian …

Diurnal Rhythmicity of the Clock Genes Per1 and Per2 in the Rat Ovary

J Fahrenkrug, B Georg, J Hannibal… - …, 2006 - academic.oup.com
Circadian rhythms are generated by endogenous clocks in the central brain oscillator, the
suprachiasmatic nucleus, and peripheral tissues. The molecular basis for the circadian clock …

Expression of circadian rhythm genes in gonadotropin-releasing hormone-secreting GT1-7 neurons

JMA Gillespie, BPK Chan, D Roy, F Cai… - …, 2003 - academic.oup.com
The center for circadian rhythms in mammals is the suprachiasmatic nucleus (SCN) of the
hypothalamus, composed of single cell circadian oscillators driven by a transcriptional …