Background Tumour-derived extracellular vesicles (EVs) play a role in tumour progression;
however, the spectrum of molecular mechanisms regulating EV secretion and cargo …

Clinically, the osteolytic phenotype is rare in prostate cancer (PCa), and the prognosis is
generally worse than that of the osteoblastic phenotype. Osteoblastic prostate cancer …

Bone metastases are still incurable and result in the development of clinical complications
and decreased survival for prostate cancer patients. Recently, a number of studies have …

Background We have previously reported that extracellular vesicles (EVs) derived from
osteoblastic, osteoclastic and mixed prostate cancer cells promote osteoclast differentiation …

Extracellular vesicles (EVs) play critical roles in regulating bone metastatic
microenvironment through mediating intercellular crosstalks. However, little is known about …

The role of extracellular vesicles (EVs) as vehicles for cell-to-cell communication between a
tumour and its environment is a relatively new concept. The hypothesis that EVs may be …

Most prostate cancer (PCa)-related deaths are caused by progression to bone metastasis.
Recently, the importance of extracellular vesicles (EVs) in pre-metastatic niche formation …

Caveolin-1 has a complex role in prostate cancer and has been suggested to be a potential
biomarker and therapeutic target. As mature caveolin-1 resides in caveolae, invaginated …

Multiple types of cancer have the specific ability to home to the bone microenvironment and
cause metastatic lesions. Despite being the focus of intense investigation, the molecular and …

A subpopulation of cancer stem cells (CSCs) plays a critical role of cancer progression,
recurrence, and therapeutic resistance. Many studies have indicated that castration-resistant …