Multiple myeloma (MM) progression closely depends on the bidirectional crosstalk between
tumor cells and the surrounding microenvironment, which leads to the creation of a tumor …

The bone marrow (BM) represents a complex microenvironment containing stromal cells,
immune cells, osteoclasts, osteoblasts, and hematopoietic cells, which are crucial for the …

Multiple myeloma (MM) is a hematologic malignancy of plasma cells (PCs). In the United
States, MM accounts for approximately 1% of all diagnoses and 2% of all cancer-related …

Multiple myeloma (MM) is characterized by the abnormal proliferation of clonal plasma cells
(PCs) in bone marrow (BM). MM-PCs progressively occupy and likely alter BM niches where …

Crosstalk between bone marrow tumour cells and surrounding cells, including bone marrow
mesenchymal stromal cells (BM-MSCs), endothelial cells and immune cells, is important for …

Introduction: Multiple myeloma (MM) is characterized by a clonal proliferation of neoplastic
plasma cells (PCs) in bone marrow (BM) and the interplay between MM PCs and the BM …

Extracellular vesicles (EVs) represent a heterogeneous group of membranous structures
shed by all kinds of cell types, which are released into the surrounding microenvironment or …

Multiple myeloma (MM), the third most frequent hematological cancer worldwide, is
characterized by the proliferation of neoplastic plasma cells in the bone marrow (BM). One of …

Multiple myeloma (MM), the second most common hematological malignancy, is an
incurable cancer of plasma cells. MM cells diffusely involves the bone marrow (BM) and …

Exosomes, extracellular nanovesicles secreted by various cell types, modulate the bone
marrow (BM) microenvironment by regulating angiogenesis, cytokine release, immune …