During pregnancy the maternal pancreatic islets of Langerhans undergo adaptive changes
to compensate for gestational insulin resistance. Kisspeptin has been shown to stimulate …

Aims/hypothesis Kisspeptin is a novel peptide identified as an endogenous ligand of the G-
protein-coupled receptor 54 (GPR-54), which plays a crucial role in puberty and …

Introduction Kisspeptins, encoded by the Kiss1 gene, are a set of related neuropeptides that
are required for activation of the mammalian reproductive axis at puberty and to maintain …

Aims/hypothesis We investigated the production of kisspeptin (KISS1) and the KISS1
receptor, GPR54, in pancreatic islets and determined the effects of exogenous kisspeptin on …

Context The human fetal adrenal (HFA) is an integral component of the fetoplacental unit
and important for the maintenance of pregnancy. Low kisspeptin levels during pregnancy …

Hypogonadotropism is a common feature of uncontrolled diabetes, for which the ultimate
mechanism remains to be elucidated. Kisspeptins, ligands of G protein–coupled receptor 54 …

Aims To investigate the effect of kisspeptin on glucose‐stimulated insulin secretion and
appetite in humans. Materials and methods In 15 healthy men (age: 25.2±1.1 years; BMI …

Purpose Kisspeptins regulate the trophoblast invasion. The disturbance of this process
might lead to the development of preeclampsia (PE). Diabetes mellitus (DM) is associated …

Early in the pathogenesis of type 2 diabetes mellitus (T2DM), dysregulated glucagon
secretion from pancreatic α cells occurs prior to impaired glucose-stimulated insulin …

Kisspeptin and its receptor are central to reproductive health acting as key regulators of the
reproductive endocrine axis in humans. Kisspeptin is most widely recognised as a regulator …