Soft connective tissues at steady state are dynamic; resident cells continually read
environmental cues and respond to them to promote homeostasis, including maintenance of …

Cells need to be anchored to extracellular matrix (ECM) to survive, yet the role of ECM in
guiding developmental processes, tissue homeostasis, and aging has long been …

Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

The extracellular matrix (ECM) is a major component of the biomechanical environment with
which cells interact, and it plays important roles in both normal development and disease …

Extracellular biophysical cues have a profound influence on a wide range of cell behaviors,
including growth, motility, differentiation, apoptosis, gene expression, adhesion, and signal …

Biophysical cues stemming from the extracellular environment are rapidly transduced into
discernible chemical messages (mechanotransduction) that direct cellular activities–placing …

The extracellular matrix (ECM) provides structural and biochemical support to cells within
tissues. An emerging body of evidence has established that the ECM plays a key role in cell …

Mechanical forces shape cells and tissues during development and adult homeostasis. In
addition, they also signal to cells via mechanotransduction pathways to control cell …

Epithelial-Mesenchymal Transition (EMT) is a critical process in embryonic development in
which epithelial cells undergo a transdifferentiation into mesenchymal cells. This process is …

Mechanical stresses modulate cell function by either activating or tuning signal transduction
pathways. Mechanotransduction, the process by which cells convert mechanical stimuli into …