The therapeutic efficacy of nanoscale anticancer drug delivery systems is severely truncated
by their low tumor-targetability and inefficient drug release at the target site. Here, we report …

Tumor-targeting nanomaterial-based chemotherapeutic drug delivery systems have been
shown to represent an efficacious approach for the treatment of cancer because of their …

In this study, we report a novel pH and temperature responsive paclitaxel-loaded drug
delivery system based on chitosan and di (ethylene glycol) methyl ether methacrylate. This …

In order to improve active tumor targeting, tumor cell uptake efficiency and circulation time of
doxorubicin (DOX) in vivo, we constructed a cleavable PEGylated hyaluronic acid nano-drug …

Many drug-resistant tumors and cancer stem cells (CSC) express elevated levels of CD44
receptor, a cellular glycoprotein binding hyaluronic acid (HA). Here, we report the synthesis …

The existence of drug resistance poses a major obstacle for the treatment of various
malignant human cancers. Here, we report on reduction-sensitive reversibly crosslinked …

Hyaluronic acid (HA), a natural polymer, has gained much attention recently because of its
good biocompatibility and extensive availability. Herein, a novel drug delivery system based …

Purpose The objective of the work was to evaluate the potential of hyaluronan-based
nanoparticles as tumor-targeting nano-systems for CD44-overexpressed cancer therapy …

Biodegradable micelles are one of the most studied systems for the delivery of hydrophobic
anticancer drugs. Their therapeutic efficacy in vivo is, however, suboptimal, partly due to …

Chemical conjugates of paclitaxel and hyaluronic acid (HA) were synthesized by utilizing a
novel HA solubilization method in a single organic phase. Hydrophilic HA was completely …