A genome-wide profiling of the humoral immune response to Chlamydia trachomatis infection reveals vaccine candidate antigens expressed in humans

J Wang, Y Zhang, C Lu, L Lei, P Yu… - The Journal of …, 2010 - journals.aai.org
A whole genome scale proteome array consisting of 908 open reading frames encoded in
Chlamydia trachomatis genome and plasmid was used to profile anti-chlamydial Ab …

P479 Immunoprofiling of Chlamydia trachomatis combining whole-proteome microarrays and high-throughput multiplex serology

K Hufnagel, N Gassert, J Butt… - Sexually Transmitted …, 2019 - search.proquest.com
Background Chronic infections with Chlamydia trachomatis (Ct) can give rise to sequelae
that include pelvic inflammatory disease (PID), chronic pelvic pain (CPP), ectopic pregnancy …

[HTML][HTML] Chlamydia trachomatis Whole-Proteome Microarray Analysis of The Netherlands Chlamydia Cohort Study

K Hufnagel, B Hoenderboom, C Harmel, JK Rohland… - Microorganisms, 2019 - mdpi.com
Chlamydia trachomatis (Ct) whole-proteome microarrays were utilized to identify antibody
patterns associated with infection; pelvic inflammatory disease (PID), tubal factor infertility …

Proteome array of antibody responses to Chlamydia trachomatis infection in nonhuman primates

C Lu, Z Sun, H Chen, L Chen, C Zhu, C Chen, C Li… - Life sciences, 2020 - Elsevier
Aims Nonhuman primates have been used to investigate pathogenic mechanisms and
evaluate immune responses following Chlamydia trachomatis inoculation. This study aimed …

Identification of immunodominant antigens of Chlamydia trachomatis using proteome microarrays

DM Molina, S Pal, MA Kayala, A Teng, PJ Kim, P Baldi… - Vaccine, 2010 - Elsevier
Chlamydia trachomatis is the most common bacterial sexually transmitted pathogen in the
world. In order to control this infection there is an urgent need to formulate a vaccine …

High-throughput proteomic screening identifies Chlamydia trachomatis antigens that are capable of eliciting T cell and antibody responses that provide protection …

MD Picard, KP Cohane, TM Gierahn, DE Higgins… - Vaccine, 2012 - Elsevier
A comprehensive proteomic screening technology was previously used to characterize T
cell responses to Chlamydia trachomatis infection. In this study, we demonstrated that T cells …

Whole genome identification of C. trachomatis immunodominant antigens after genital tract infections and effect of antibiotic treatment of pigtailed macaques

DL Patton, A Teng, A Randall, X Liang, PL Felgner… - Journal of …, 2014 - Elsevier
The cervix and/or fallopian tubes of pigtailed macaques were experimentally infected with
Chlamydia trachomatis. Their sera were collected at varying time points and screened for …

Identification of Immunodominant Antigens by Probing a Whole Chlamydia trachomatis Open Reading Frame Proteome Microarray Using Sera from Immunized Mice

MI Cruz-Fisher, C Cheng, G Sun, S Pal… - Infection and …, 2011 - Am Soc Microbiol
Chlamydia trachomatis infections can lead to severe chronic complications, including
trachoma, ectopic pregnancy, and infertility. The only effective approach to disease control is …

Profiling of Human Antibody Responses to Chlamydia trachomatis Urogenital Tract Infection Using Microplates Arrayed with 156 Chlamydial Fusion Proteins

J Sharma, Y Zhong, F Dong, JM Piper… - Infection and …, 2006 - Am Soc Microbiol
The available chlamydial genome sequences have made it possible to comprehensively
analyze host responses to all chlamydial proteins, which is essential for further …

[HTML][HTML] Immunoprofiling of Chlamydia trachomatis using whole-proteome microarrays generated by on-chip in situ expression

K Hufnagel, S Lueong, M Willhauck-Fleckenstein… - Scientific reports, 2018 - nature.com
Abstract Using Chlamydia trachomatis (Ct) as a complex model organism, we describe a
method to generate bacterial whole-proteome microarrays using cell-free, on-chip protein …