Cascade of inflammatory, fibrotic processes, and stress-induced senescence in chronic GVHD-related dry eye disease

Y Ogawa, Y Kawakami, K Tsubota - International journal of molecular …, 2021 - mdpi.com
Ocular graft-versus-host disease (GVHD) is a major complication after allogeneic
hematopoietic stem cell transplantation. Ocular GVHD affects recipients' visual function and …

Senescence‐associated secretory phenotype promotes chronic ocular graft‐vs‐host disease in mice and humans

M Yamane, S Sato, E Shimizu, S Shibata… - The FASEB …, 2020 - Wiley Online Library
Chronic graft‐vs‐host disease (cGVHD) is a multifactorial inflammatory disease that affects
patients undergoing hematopoietic stem cell transplantation. Multiple organs, including the …

Recent advances in ocular graft-versus-host disease

X Cheng, R Huang, S Huang, W Fan, R Yuan… - Frontiers in …, 2023 - frontiersin.org
Ocular graft-versus-host-disease (GVHD) remains a significant clinical complication after
allogeneic hematopoietic stem cell transplantation. Impaired visual function, pain, and other …

Baseline profiles of ocular surface and tear dynamics after allogeneic hematopoietic stem cell transplantation in patients with or without chronic GVHD-related dry eye

Y Wang, Y Ogawa, M Dogru, Y Tatematsu… - Bone marrow …, 2010 - nature.com
We evaluated ocular surface alterations in allogeneic hematopoietic stem cell
transplantation (HSCT) recipients with or without chronic GVHD-related dry eye in a …

The subtle role of para-inflammation in modulating the progression of dry eye disease

M Rolando, S Barabino - Ocular Immunology and Inflammation, 2021 - Taylor & Francis
In patients with DED, the continuous stimuli induced by excessive or persistent cold fiber
sensors and overstimulation of nociceptors, as well as tear hyperosmolarity induced by …

[HTML][HTML] Biomarkers in ocular graft-versus-host disease: implications for the involvement of B cells

Z Shen, J Ma, R Peng, B Hu, Y Zhao, S Liu… - … and Cellular Therapy, 2022 - Elsevier
Graft-versus-host disease (GVHD) is an immune-mediated inflammatory disease resulting
from destruction of host tissue by donor immunoreactive cells and occurs in 30% to 70% of …

The role and treatment of inflammation in dry eye disease

A Yagci, C Gurdal - International Ophthalmology, 2014 - Springer
Dry eye syndrome is a common ocular surface problem, affects 10–30% of the population,
especially in those who are older than 40 years. As a consequence of the demographic …

Impact of aging on the pathophysiology of dry eye disease: A systematic review and meta-analysis

K Kitazawa, T Inomata, K Shih, JWB Hughes, N Bozza… - The Ocular Surface, 2022 - Elsevier
Purpose Dry eye disease (DED) is a common age-related ocular surface disease. However,
it is unknown how aging influences the ocular surface microenvironment. This systematic …

Potential New Target for Dry Eye Disease—Oxidative Stress

J Bu, Y Liu, R Zhang, S Lin, J Zhuang, L Sun, L Zhang… - Antioxidants, 2024 - mdpi.com
Dry eye disease (DED) is a multifactorial condition affecting the ocular surface. It is
characterized by loss of tear film homeostasis and accompanied by ocular symptoms that …

Parainflammation associated with advanced glycation endproduct stimulation of RPE in vitro: implications for age-related degenerative diseases of the eye

T Lin, GB Walker, K Kurji, E Fang, G Law, SS Prasad… - Cytokine, 2013 - Elsevier
Age related macular degeneration (AMD) is one of the leading causes of blindness in
Western society. A hallmark of early stage AMD are drusen, extracellular deposits that …