Mitochondria are a main source of cellular energy. Oxidative phosphorylation (OXPHOS) is
the major process of aerobic respiration. Enzyme complexes of the electron transport chain …

Mitochondria use oxygen as the final acceptor of the respiratory chain, but its incomplete
reduction can also produce reactive oxygen species (ROS), especially superoxide. Acute …

Physiological hypoxia results in a host of responses that include increased ventilation,
constriction of the pulmonary artery, and a cellular transcriptional program that promotes …

All eukaryotic cells utilize oxidative phosphorylation to maintain their high‐energy
phosphate stores. Mitochondrial oxygen consumption is required for ATP generation, and …

Hypoxia promotes physiological processes such as energy metabolism, angiogenesis, cell
proliferation, and cell viability through the transcription factor Hypoxia Inducible Factor (HIF) …

Proper coordination between glycolysis and respiration is essential, yet the regulatory
mechanisms involved in sensing respiratory chain defects and modifying mitochondrial …

Mitochondrial reactive oxygen species (ROS) can be either detrimental or beneficial
depending on the amount, duration, and location of their production. Mitochondrial complex I …

Hypoxia triggers several mechanisms to adapt cells to a low oxygen environment.
Mitochondria are major consumers of oxygen and a potential source of reactive oxygen …

Decreased oxygen availability (hypoxia) promotes physiological processes such as energy
metabolism, angiogenesis, cell proliferation and cell viability through the transcription factor …

Mitochondria play an important role in sensing both acute and chronic hypoxia in the
pulmonary vasculature, but their primary oxygen-sensing mechanism and contribution to …