The use of reliable biomarkers is becoming increasingly important for the improved
management of patients with acute and chronic kidney diseases. Recent developments …

Introduction Chronic kidney disease (CKD) is a silent disease. Most CKD patients are
unaware of their condition during the early stages of the disease which poses a challenge …

The current unidimensional paradigm of kidney disease detection is incompatible with the
complexity and heterogeneity of renal pathology. The diagnosis of kidney disease has …

The tools of functional genomics and proteomics have provided us with promising novel
biomarkers for acute kidney injury and chronic kidney disease. It will be important in future …

Kidney damage can be induced by ischemia, autoimmune diseases, hypertension, allograft
rejection, metabolic or genetic disorders, infections or toxins. The influence of these factors …

Different biochemical markers exist in both blood and urine for assessing renal function.
Most of these biomarkers have advantages and limitations associated with their use, which …

The clinical assessment and management of pa-tients with known or suspected kidney
disease has been aided for decades by biomarkers, a term defined by a National Institutes …

Animal models and human studies have been useful in dissecting the molecular
mechanisms of renal disease and finding new disease targets; however, translation of these …

The high incidence of cardiovascular events in chronic kidney disease (CKD) warrants an
accurate evaluation of risk aimed at reducing the burden of disease and its consequences …

Results After multivariable adjustment and correction for multiple testing, 46 different
proteins were associated with histopathologic lesions. The top-performing markers positively …