[HTML][HTML] The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets

J van Riet, HJG van de Werken, E Cuppen… - Nature …, 2021 - nature.com
Metastatic and locally-advanced neuroendocrine neoplasms (aNEN) form clinically and
genetically heterogeneous malignancies, characterized by distinct prognoses based upon …

Overview of the 2022 WHO classification of neuroendocrine neoplasms

G Rindi, O Mete, S Uccella, O Basturk, S La Rosa… - Endocrine …, 2022 - Springer
In this review, we detail the changes and the relevant features that are applied to
neuroendocrine neoplasms (NENs) in the 2022 WHO Classification of Endocrine and …

[HTML][HTML] Genetic and epigenetic drivers of neuroendocrine tumours (NET)

A Di Domenico, T Wiedmer, I Marinoni… - Endocrine-related …, 2017 - erc.bioscientifica.com
Neuroendocrine tumours (NET) of the gastrointestinal tract and the lung are a rare and
heterogeneous group of tumours. The molecular characterization and the clinical …

[HTML][HTML] Genomic landscape of pancreatic neuroendocrine tumours: the International Cancer Genome Consortium

A Mafficini, A Scarpa - Journal of Endocrinology, 2018 - joe.bioscientifica.com
Neuroendocrine tumours (NETs) may arise throughout the body and are a highly
heterogeneous, relatively rare class of neoplasms difficult to study also for the lack of …

[HTML][HTML] The molecular characteristics of high-grade gastroenteropancreatic neuroendocrine neoplasms

A Venizelos, H Elvebakken, A Perren… - Endocrine-related …, 2022 - erc.bioscientifica.com
High-grade (HG) gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are rare
but have a very poor prognosis and represent a severely understudied class of tumours …

Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors

P Cejas, Y Drier, KMA Dreijerink, LAA Brosens… - Nature medicine, 2019 - nature.com
Most pancreatic neuroendocrine tumors (PNETs) do not produce excess hormones and are
therefore considered 'non-functional',–. As clinical behaviors vary widely and distant …

Genetics and epigenetics of gastroenteropancreatic neuroendocrine neoplasms

A Mafficini, A Scarpa - Endocrine reviews, 2019 - academic.oup.com
Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs) are heterogeneous
regarding site of origin, biological behavior, and malignant potential. There has been a rapid …

[HTML][HTML] An organoid biobank of neuroendocrine neoplasms enables genotype-phenotype mapping

K Kawasaki, K Toshimitsu, M Matano, M Fujita, M Fujii… - Cell, 2020 - cell.com
Gastroenteropancreatic (GEP) neuroendocrine neoplasm (NEN) that consists of
neuroendocrine tumor and neuroendocrine carcinoma (NEC) is a lethal but under …

[HTML][HTML] Pancreatic neuroendocrine tumors: molecular mechanisms and therapeutic targets

CK Maharjan, PH Ear, CG Tran, JR Howe… - Cancers, 2021 - mdpi.com
Simple Summary Pancreatic neuroendocrine tumors (pNETs) are rare, indolent cancers
whose causation is only partly understood. An increasing number of studies have uncovered …

Biology and evolution of poorly differentiated neuroendocrine tumors

DS Rickman, H Beltran, F Demichelis, MA Rubin - Nature medicine, 2017 - nature.com
Neuroendocrine (NE) cancers are a diverse group of neoplasms typically diagnosed and
treated on the basis of their site of origin. This Perspective focuses on advances in our …