Over the centuries, cancer has been considered one of the significant health threats. It holds
the position in the list of deadliest diseases over the globe. In women, breast cancer is the …

Cell-division protein kinases (CDKs) are gorgeous examples of targets for the helpful
treatment of cancer by using multi-target inhibitors. Specifically, targeting cell-division …

Cyclin-Dependent Kinase 6 (CDK6) plays an important role in cancer progression, and thus,
it is considered as an attractive drug target in anticancer therapeutics. This study presents an …

CDK2, which interacts with cyclin A and cyclin E, is an important member of the CDK family.
Having been proved to be associated with many diseases for its vital role in cell cycle, CDK2 …

P53 is eminent tumour suppressor protein that plays a prominent role in cell cycle arrest,
DNA repair, senescence, differentiation and initiation of apoptosis. P53 is an attractive drug …

Abstract The cyclin-dependent kinase-2 (CDK2) belongs to the protein kinase family and its
overexpression leads to an unusual regulation of cell-cycle which directly linked with …

Cyclin-dependent kinases (CDKs) are known for their vital role in regulating cell cycle
progression through protein-kinase interactions. CDKs also help in regulating transcription …

Inspired by the synergistic effects of hetero-aromatic scaffolds on curcumin, a novel array of
pyrazoline substituted curcumin analogs was designed. Multi-scale computational studies …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and characterized by
brain cell death, memory loss and is the most common form of dementia. Although AD has …

Casein kinase 2 (CK2) is a conserved serine/threonine-protein kinase involved in
hematopoietic cell survival, cell cycle control, DNA repair, and other cellular processes. It …