Conspectus The cyclic GMP-AMP synthase-stimulator interferon gene (cGAS-STING)
pathway is an emerging therapeutic target for the prophylaxis and therapy of a variety of …

Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is
a DNA sensor that elicits a robust type I interferon response by recognizing ubiquitous …

Activation of the cyclic guanosine monophosphate-adenosine monophosphate synthase
(cGAS)-stimulator of interferon genes (STING) pathway has great potential to promote …

The intricate interplay between the human immune system and cancer development
underscores the central role of immunotherapy in cancer treatment. Within this landscape …

Stimulator of interferon genes (STING) are located in the endoplasmic reticulum of cells,
which have been demonstrated to show considerable potentials to achieve efficient …

Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor and innate
immune response initiator. Binding with exogenous or endogenous nucleic acids, cGAS …

Abstract STING (Stimulator of Interferon Genes) agonists have emerged as promising agents
in the field of cancer immunotherapy, owing to their excellent capacity to activate the innate …

Cytosolic DNA sensing, the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-
STING) pathway, is an important novel role in the immune system. Multiple STING agonists …

Cellular recognition of microbial DNA is an evolutionarily conserved mechanism by which
the innate immune system detects pathogens. Cyclic GMP-AMP synthase (cGAS) and its …

Innate immunity plays an important role not only during infection but also homeostatic role
during stress conditions. Activation of the immune system including innate immune response …