Engineering and delivery of cGAS-STING immunomodulators for the immunotherapy of cancer and autoimmune diseases
S Zhou, F Cheng, Y Zhang, T Su… - Accounts of chemical …, 2023 - ACS Publications
Conspectus The cyclic GMP-AMP synthase-stimulator interferon gene (cGAS-STING)
pathway is an emerging therapeutic target for the prophylaxis and therapy of a variety of …
pathway is an emerging therapeutic target for the prophylaxis and therapy of a variety of …
Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseases
Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is
a DNA sensor that elicits a robust type I interferon response by recognizing ubiquitous …
a DNA sensor that elicits a robust type I interferon response by recognizing ubiquitous …
Agonists and Inhibitors of the cGAS-STING Pathway
X Yu, L Cai, J Yao, C Li, X Wang - Molecules, 2024 - mdpi.com
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is
pivotal in immunotherapy. Several agonists and inhibitors of the cGAS-STING pathway have …
pivotal in immunotherapy. Several agonists and inhibitors of the cGAS-STING pathway have …
[HTML][HTML] Emerging mechanisms and implications of cGAS-STING signaling in cancer immunotherapy strategies
J Zhang, S Yu, Q Peng, P Wang… - Cancer Biology & …, 2024 - ncbi.nlm.nih.gov
The intricate interplay between the human immune system and cancer development
underscores the central role of immunotherapy in cancer treatment. Within this landscape …
underscores the central role of immunotherapy in cancer treatment. Within this landscape …
Nanoparticle‐mediated STING agonist delivery for enhanced cancer immunotherapy
Q Zhou, Y Zhou, T Li, Z Ge - Macromolecular Bioscience, 2021 - Wiley Online Library
Stimulator of interferon genes (STING) are located in the endoplasmic reticulum of cells,
which have been demonstrated to show considerable potentials to achieve efficient …
which have been demonstrated to show considerable potentials to achieve efficient …
Nanodelivery of cGAS-STING activators for tumor immunotherapy
Activation of the cyclic guanosine monophosphate-adenosine monophosphate synthase
(cGAS)-stimulator of interferon genes (STING) pathway has great potential to promote …
(cGAS)-stimulator of interferon genes (STING) pathway has great potential to promote …
[HTML][HTML] Overcoming challenges in the delivery of STING agonists for cancer immunotherapy: a comprehensive review of strategies and future perspectives
C Huang, N Shao, Y Huang, J Chen, D Wang, G Hu… - Materials Today Bio, 2023 - Elsevier
Abstract STING (Stimulator of Interferon Genes) agonists have emerged as promising agents
in the field of cancer immunotherapy, owing to their excellent capacity to activate the innate …
in the field of cancer immunotherapy, owing to their excellent capacity to activate the innate …
cGAS/STING: novel perspectives of the classic pathway
M Gao, Y He, H Tang, X Chen, S Liu, Y Tao - Molecular Biomedicine, 2020 - Springer
Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor and innate
immune response initiator. Binding with exogenous or endogenous nucleic acids, cGAS …
immune response initiator. Binding with exogenous or endogenous nucleic acids, cGAS …
cGAS-STING, an important pathway in cancer immunotherapy
M Jiang, P Chen, L Wang, W Li, B Chen, Y Liu… - Journal of hematology & …, 2020 - Springer
Cytosolic DNA sensing, the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-
STING) pathway, is an important novel role in the immune system. Multiple STING agonists …
STING) pathway, is an important novel role in the immune system. Multiple STING agonists …
Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy
J Zheng, J Mo, T Zhu, W Zhuo, Y Yi, S Hu, J Yin… - Molecular cancer, 2020 - Springer
Cellular recognition of microbial DNA is an evolutionarily conserved mechanism by which
the innate immune system detects pathogens. Cyclic GMP-AMP synthase (cGAS) and its …
the innate immune system detects pathogens. Cyclic GMP-AMP synthase (cGAS) and its …
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