Role of impaired mitochondrial dynamics processes in the pathogenesis of Alzheimer's disease

AV Blagov, AV Grechko, NG Nikiforov… - International Journal of …, 2022 - mdpi.com
Mitochondrial dysfunction is now recognized as a contributing factor to neurodegenerative
diseases, including Alzheimer's disease (AD). Mitochondria are signaling organelles with a …

[HTML][HTML] Mitochondrial dynamics and transport in Alzheimer's disease

PJ Flannery, E Trushina - Molecular and Cellular Neuroscience, 2019 - Elsevier
Mitochondrial dysfunction is now recognized as a contributing factor to the early pathology of
multiple human conditions including neurodegenerative diseases. Mitochondria are …

Abnormal mitochondrial dynamics—a novel therapeutic target for Alzheimer's disease?

B Su, X Wang, D Bonda, G Perry, M Smith… - Molecular neurobiology, 2010 - Springer
Mitochondria are dynamic organelles that undergo continuous fission and fusion, which
could affect all aspects of mitochondrial function. Mitochondrial dysfunction has been well …

Alterations in mitochondrial quality control in Alzheimer's disease

Q Cai, P Tammineni - Frontiers in cellular neuroscience, 2016 - frontiersin.org
Mitochondrial dysfunction is one of the earliest and most prominent features in the brains of
Alzheimer's disease (AD) patients. Recent studies suggest that mitochondrial dysfunction …

Mitochondrial dynamics: a key role in neurodegeneration and a potential target for neurodegenerative disease

D Yang, J Ying, X Wang, T Zhao, S Yoon… - Frontiers in …, 2021 - frontiersin.org
In neurodegenerative diseases, neurodegeneration has been related to several
mitochondrial dynamics imbalances such as excessive fragmentation of mitochondria …

Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease

X Zhu, G Perry, MA Smith… - Journal of Alzheimer's …, 2013 - content.iospress.com
Mitochondrial dysfunction is one of the most early and prominent features in vulnerable
neurons in the brain of Alzheimer's disease (AD) patients. Recent studies suggest that …

Mechanisms of mitochondrial malfunction in Alzheimer's disease: new therapeutic hope

SU Nabi, A Khan, EM Siddiqui… - Oxidative medicine …, 2022 - Wiley Online Library
Mitochondria play a critical role in neuron viability or death as it regulates energy
metabolism and cell death pathways. They are essential for cellular energy metabolism …

Mitochondrial dysfunction as a driver of cognitive impairment in Alzheimer's disease

C Sharma, S Kim, Y Nam, UJ Jung, SR Kim - International Journal of …, 2021 - mdpi.com
Alzheimer's disease (AD) is the most frequent cause of age-related neurodegeneration and
cognitive impairment, and there are currently no broadly effective therapies. The underlying …

Disturbed mitochondrial dynamics and neurodegenerative disorders

F Burté, V Carelli, PF Chinnery… - Nature reviews …, 2015 - nature.com
Mitochondria form a highly interconnected tubular network throughout the cell via a dynamic
process, with mitochondrial segments fusing and breaking apart continuously. Strong …

Mitochondrial perturbation in Alzheimer's disease and diabetes

F Akhter, D Chen, SF Yan, SS Yan - Progress in molecular biology and …, 2017 - Elsevier
Mitochondria are well-known cellular organelles that play a vital role in cellular
bioenergetics, heme biosynthesis, thermogenesis, calcium homeostasis, lipid catabolism …