Opioid receptors have been a target of pharmacological manipulation in alcohol use
disorder (AUD) recovery protocols for many years. Aerobic exercise, a common adjunct in …

Exercise has increasingly been recognized as an adjunctive therapy for alcohol-use
disorder (AUD), yet our understanding of its underlying neurological mechanisms remains …

Exercise is increasingly utilized in treating AUD, but its impact on mesolimbic circuitry,
specifically the Dynorphin-Kappa Opioid Receptor (KOR) system, remains unclear …

The dopaminergic projections from the ventral midbrain to the striatum have long been
implicated in mediating motivated behaviors and addiction. Previously it was demonstrated …

Acute ethanol exposure is known to stimulate the dopamine system; however, chronic
exposure has been shown to downregulate the dopamine system. In rodents, chronic …

Our laboratory has previously demonstrated that daily forced swim stress (FSS) prior to
ethanol drinking sessions facilitates enhanced ethanol consumption in mice with a history of …

Evidence has demonstrated that dynorphin (DYN) and the kappa opioid receptor (KOR)
system contribute to various psychiatric disorders, including anxiety, depression, and …

Binge drinking is a major concern, especially among college students. Positive results have
been demonstrated in clinical trials that utilized exercise to treat alcohol use disorder, but …

Introduction Studies in laboratory animals and humans indicate that endogenous opioids
play an important role in regulating the rewarding value of various drugs, including ethanol …

Although far from conclusive, evidence implicating the endogenous opioid system in the
development and maintenance of alcoholism is growing. Currently available data suggest …