It is believed that cardiac remodeling due to geometric and structural changes is a major
mechanism for the progression of heart failure in different pathologies including …

Cardiovascular disease is a major cause of death and thus a great deal of effort has been
made in salvaging the diseased myocardium. Although various factors have been identified …

Cardiac hypertrophy (CH), characterized by the enlargement of cardiomyocytes, fibrosis and
apoptosis, is one of the leading causes of death worldwide. Despite the advances in …

Theconcept and clinical implication of left ventricular remodeling have been gradually
extended. Cardiac re-modeling plays important roles in the progression of car-diovascular …

Various procedures such as angioplasty, thrombolytic therapy, coronary bypass surgery,
and cardiac transplantation are invariably associated with ischemia–reperfusion (I/R) injury …

A milestone in the progression of congestive heart failure (CHF) is myocardial remodeling.
Left ventricular (LV) remodeling during the progression of CHF is accompanied by changes …

Congestive heart failure is a complex pathophysiological process in which a significant
biological underpinning is left ventricular (LV) failure. Part of the natural advancement to …

Cardiomyocytes are terminally differentiated cells and thus do not have the ability to dilute
damaged proteins and organelles by cell division. Thus, proteolytic and recycling systems …

The ubiquitin-proteasome system (UPS) is the major nonlysosomal pathway for intracellular
protein degradation, generally requiring a covalent linkage of one or more chains of …

Cardiovascular disease is the leading cause of death in the US and other developed
countries. Metabolic syndrome, including obesity, diabetes/insulin resistance, hypertension …