Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disorder driven by
unrelenting extracellular matrix deposition. Fibroblasts are recognized as the central …

The bleomycin-induced rodent lung fibrosis model is commonly used to study mechanisms
of lung fibrosis and to test potential therapeutic interventions, despite the well recognized …

Pulmonary fibrosis (PF) is a form of chronic lung disease characterized by pathologic
epithelial remodeling and accumulation of extracellular matrix (ECM). To comprehensively …

Pathological remodeling of the extracellular matrix (ECM) by fibroblasts leads to organ
failure. Development of idiopathic pulmonary fibrosis (IPF) is characterized by a progressive …

Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible, and rapidly fatal interstitial
lung disease marked by the replacement of lung alveoli with dense fibrotic matrices …

Progressive pulmonary fibrosis results from a dysfunctional tissue repair response and is
characterized by fibroblast proliferation, activation, and invasion and extracellular matrix …

Pulmonary fibrosis is characterized by accumulation of activated fibroblasts that produce
excessive amounts of extracellular matrix components such as collagen type I. However, the …

Idiopathic pulmonary fibrosis (IPF) is a form of progressive interstitial lung disease with
unknown etiology. Due to a lack of effective treatment, IPF is associated with a high mortality …

Idiopathic pulmonary fibrosis (IPF) is a progressive disease of the middle aged and elderly
with a prevalence of one million persons worldwide. The fibrosis spreads from affected …

The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of cell
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …