[HTML][HTML] Luteolin Exerts Neuroprotection via Modulation of the p62/Keap1/Nrf2 Pathway in Intracerebral Hemorrhage

X Tan, Y Yang, J Xu, P Zhang, R Deng… - Frontiers in …, 2020 - frontiersin.org
Upregulation of neuronal oxidative stress is involved in the progression of secondary brain
injury (SBI) following intracerebral hemorrhage (ICH). In this study, we investigated the …

[HTML][HTML] Luteolin alleviates neuroinflammation via downregulating the TLR4/TRAF6/NF-κB pathway after intracerebral hemorrhage

Y Yang, X Tan, J Xu, T Wang, T Liang, X Xu… - Biomedicine & …, 2020 - Elsevier
The activation of microglia and inflammatory responses is essential for the process of
intracerebral hemorrhage (ICH)-induced secondary brain injury (SBI). In this study, we …

Luteolin Confers Cerebroprotection after Subarachnoid Hemorrhage by Suppression of NLPR3 Inflammasome Activation through Nrf2‐Dependent Pathway

ZH Zhang, JQ Liu, CD Hu, XT Zhao… - Oxidative Medicine …, 2021 - Wiley Online Library
Luteolin (LUT) possesses multiple biologic functions and has beneficial effects for
cardiovascular and cerebral vascular diseases. Here, we investigated the protective effects …

Posttraumatic administration of luteolin protects mice from traumatic brain injury: implication of autophagy and inflammation

J Xu, H Wang, X Lu, K Ding, L Zhang, J He, W Wei… - Brain research, 2014 - Elsevier
Secondary brain insult induced by traumatic brain injury (TBI), including excitotoxicity,
oxidative stress, inflammatory response, and neuronal degeneration, is sensitive to …

Luteolin provides neuroprotection in models of traumatic brain injury via the Nrf2–ARE pathway

J Xu, H Wang, K Ding, L Zhang, C Wang, T Li… - Free Radical Biology …, 2014 - Elsevier
Luteolin has recently been proven to exert neuroprotection in a variety of neurological
diseases; however, its roles and the underlying mechanisms in traumatic brain injury are not …

[HTML][HTML] Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS-and/or NF-κB-mediated NLRP3 inflammasome …

J Zeng, Y Chen, R Ding, L Feng, Z Fu, S Yang… - Journal of …, 2017 - Springer
Background Intracerebral hemorrhage (ICH) induces potently oxidative stress responses
and inflammatory processes. Isoliquiritigenin (ILG) is a flavonoid with a chalcone structure …

[HTML][HTML] Cepharanthine attenuates cerebral ischemia/reperfusion injury by reducing NLRP3 inflammasome-induced inflammation and oxidative stress via inhibiting 12 …

J Zhao, X Piao, Y Wu, S Liang, F Han, Q Liang… - Biomedicine & …, 2020 - Elsevier
Cepharanthine (CEP) is a potential candidate for treatment of cerebral ischemia/reperfusion
(I/R) injury, due to its anti-inflammatory and anti-oxidative properties. To investigate the effect …

Mechanism of baicalein in brain injury after intracerebral hemorrhage by inhibiting the ROS/NLRP3 inflammasome pathway

X Chen, Y Zhou, S Wang, W Wang - Inflammation, 2022 - Springer
Intracerebral hemorrhage (ICH) is a devastating subtype of stroke with high
disability/mortality. Baicalein has strong anti-inflammatory activity. This study aims to explore …

(‐)‐Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathways

CF Chang, S Cho, J Wang - Annals of clinical and translational …, 2014 - Wiley Online Library
Objective In the wake of intracerebral hemorrhage (ICH), a devastating stroke with no
effective treatment, hemoglobin/iron‐induced oxidative injury leads to neuronal loss and …

Cordycepin confers neuroprotection in mice models of intracerebral hemorrhage via suppressing NLRP3 inflammasome activation

Y Cheng, Y Wei, W Yang, Y Song, H Shang, Y Cai… - Metabolic Brain …, 2017 - Springer
Neuroinflammation has been recognized as a major contributor to brain injury caused by
intracerebral hemorrhage (ICH). Nucleotide-binding oligomerization domain-like receptor …