[HTML][HTML] Immunosuppression broadens evolutionary pathways to drug resistance and treatment failure during Acinetobacter baumannii pneumonia in mice
W Huo, LM Busch, J Hernandez-Bird, E Hamami… - Nature …, 2022 - nature.com
Acinetobacter baumannii is increasingly refractory to antibiotic treatment in healthcare
settings. As is true of most human pathogens, the genetic path to antimicrobial resistance …
settings. As is true of most human pathogens, the genetic path to antimicrobial resistance …
[HTML][HTML] Antibiotic susceptibility signatures identify potential antimicrobial targets in the Acinetobacter baumannii cell envelope
E Geisinger, NJ Mortman, Y Dai, M Cokol… - Nature …, 2020 - nature.com
A unique, protective cell envelope contributes to the broad drug resistance of the
nosocomial pathogen Acinetobacter baumannii. Here we use transposon insertion …
nosocomial pathogen Acinetobacter baumannii. Here we use transposon insertion …
In vitro and in vivo reduced fitness and virulence in ciprofloxacin‐resistant Acinetobacter baumannii
Y Smani, R López‐Rojas… - Clinical Microbiology …, 2012 - Wiley Online Library
Clin Microbiol Infect 2012; 18: E1–E4 Abstract Limited data on relative fitness and virulence
of antimicrobial‐resistant Acinetobacter baumannii are known. We aimed to study the …
of antimicrobial‐resistant Acinetobacter baumannii are known. We aimed to study the …
A high-frequency phenotypic switch links bacterial virulence and environmental survival in Acinetobacter baumannii
Antibiotic-resistant infections lead to 700,000 deaths per year worldwide. The roles of
phenotypically diverse subpopulations of clonal bacteria in the progression of diseases are …
phenotypically diverse subpopulations of clonal bacteria in the progression of diseases are …
[HTML][HTML] Portrait of a killer: Uncovering resistance mechanisms and global spread of Acinetobacter baumannii
AK Cain, M Hamidian - PLoS Pathogens, 2023 - journals.plos.org
Antibiotic resistance is a growing global concern in the field of medicine as it renders
bacterial infections difficult to treat and often more severe. Acinetobacter baumannii is a …
bacterial infections difficult to treat and often more severe. Acinetobacter baumannii is a …
[HTML][HTML] Genome dynamics of multidrug-resistant Acinetobacter baumannii during infection and treatment
Background Limited treatment options are available for patients infected with multidrug
(MDR)-or pan-drug (PDR)-resistant bacterial pathogens, resulting in infections that can …
(MDR)-or pan-drug (PDR)-resistant bacterial pathogens, resulting in infections that can …
The landscape of phenotypic and transcriptional responses to ciprofloxacin in Acinetobacter baumannii: acquired resistance alleles modulate drug-induced SOS …
E Geisinger, G Vargas-Cuebas, NJ Mortman, S Syal… - MBio, 2019 - Am Soc Microbiol
The emergence of fluoroquinolone resistance in nosocomial pathogens has restricted the
clinical efficacy of this antibiotic class. In Acinetobacter baumannii, the majority of clinical …
clinical efficacy of this antibiotic class. In Acinetobacter baumannii, the majority of clinical …
Ecological and evolutionary mechanisms driving within-patient emergence of antimicrobial resistance
The ecological and evolutionary mechanisms of antimicrobial resistance (AMR) emergence
within patients and how these vary across bacterial infections are poorly understood …
within patients and how these vary across bacterial infections are poorly understood …
[HTML][HTML] Antibiotic resistance of pathogenic Acinetobacter species and emerging combination therapy
The increasing antibiotic resistance of Acinetobacter species in both natural and hospital
environments has become a serious problem worldwide in recent decades. Because of both …
environments has become a serious problem worldwide in recent decades. Because of both …
Manipulation of natural transformation by AbaR-type islands promotes fixation of antibiotic resistance in Acinetobacter baumannii
R Tuffet, G Carvalho, AS Godeux… - Proceedings of the …, 2024 - pnas.org
The opportunistic pathogen Acinetobacter baumannii, carries variants of A. baumannii
resistance islands (AbaR)-type genomic islands conferring multidrug resistance. Their …
resistance islands (AbaR)-type genomic islands conferring multidrug resistance. Their …
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