[HTML][HTML] Chlorpheniramine attenuates histamine-mediated aquaporin 5 downregulation in human nasal epithelial cells via suppression of NF-κB activation

YL Chang, CS Lin, HW Wang, KR Jian… - International journal of …, 2017 - ncbi.nlm.nih.gov
Background: Aquaporin 5 (AQP5) is most likely the primary water channel in the human
nasal mucosa and acts as a key tight junction protein. The signaling cascades responsible …

Dexamethasone attenuates methacholine‐mediated aquaporin 5 downregulation in human nasal epithelial cells via suppression of NF‐κB activation

YL Chang, KR Jian, CS Lin… - International Forum of …, 2018 - Wiley Online Library
Background Cholinergic stimulation plays a major role in inflammatory airway diseases.
However, its role in airway surface liquid homeostasis and aquaporin 5 (AQP5) regulation …

Histamine downregulates aquaporin 5 in human nasal epithelial cells

W Wang, X Wang, L Ma… - American journal of …, 2015 - journals.sagepub.com
Background Aquaporin 5 (AQP5) is a water-specific channel protein. It is thought to be a key
participant in fluid secretion and a rate-limiting barrier to the secretion seen during allergic …

[HTML][HTML] Effects of glucocorticoid on the expression and regulation of aquaporin 5 in the paranasal sinus of rats with chronic rhinosinusitis

CJ Yu, XY Cui, L Lu, J Yang… - Experimental and …, 2017 - spandidos-publications.com
Aquaporins (AQPs) are water-specific membrane channel proteins that regulate water
homeostasis for cells and organisms. AQP5 serves an important role in the maintenance of …

Role of cAMP-PKA/CREB pathway in regulation of AQP 5 production in rat nasal epithelium.

W Wang, M Zheng - Rhinology, 2011 - europepmc.org
Objectives Aquaporin 5 (AQP5) is a water-specific channel protein. In this study, we
investigated the possible role of the cyclic adenosine monophosphate-protein kinase …

Aquaporin 5 increases keratinocyte-derived chemokine expression and NF-κB activity through ERK activation

Y Sakamoto, A Hisatsune, H Katsuki, I Horie… - Biochemical and …, 2014 - Elsevier
Abstract Aquaporin-5 (AQP5) is a water-selective channel protein that is expressed in
submucosal glands and alveolar epithelial cells in the lungs. Recent studies have revealed …

Expression and localization of aquaporin 1, 2, 3, 4, and 5 in human nasal mucosa

S Seno, T Ogawa, M Shibayama… - American journal of …, 2012 - journals.sagepub.com
Background Aquaporins (AQPs) are water-specific membrane channel proteins that regulate
water homeostasis for cells and organisms. The purpose of this study was to elucidate the …

Nuclear factor kappa B pathway down-regulates aquaporin 5 in the nasal mucosa of rats with allergic rhinitis

W Wang, M Zheng - European Archives of Oto-Rhino-Laryngology, 2011 - Springer
Nuclear factor kappa B (NF-κB) induces gene transcription by binding CREB-binding protein
(CBP). The aim of the study was to detect the mechanisms by which NF-κB pathway …

Glycyrrhizin attenuates histamine-mediated MUC5AC upregulation, inflammatory cytokine production, and aquaporin 5 downregulation through suppressing the NF …

H Li, D Guo, L Zhang, X Feng - Chemico-biological interactions, 2018 - Elsevier
Allergic rhinitis (AR) is a chronic respiratory inflammatory disease. Glycyrrhizin is a main
bioactive component of the licorice root extract and exhibits anti-inflammatory activity …

Changes in water channel aquaporin 1 and aquaporin 5 in the small airways and the alveoli in a rat asthma model

A Ablimit, B Hasan, W Lu, W Qin, Q Wushouer… - Micron, 2013 - Elsevier
OBJECTIVES: To examine changes in aquaporin 1 (AQP1) and aquaporin 5 (AQP5) in the
small airways and alveoli in a rat asthma model. METHOD: Forty Wistar rats were randomly …