Hypermethylation of the hMLH1 Promoter in Colon Cancer with Microsatellite Instability
JM Cunningham, ER Christensen, DJ Tester, CY Kim… - Cancer research, 1998 - AACR
Recent studies have demonstrated the presence of microsatellite instability (MSI) in tumors
from patients with hereditary nonpolyposis colon cancer and in a subset of patients with …
from patients with hereditary nonpolyposis colon cancer and in a subset of patients with …
Methylation of the hMLH1 promoter but no hMLH1 mutations in sporadic gastric carcinomas with high‐level microsatellite instability
RAU Bevilacqua, AJG Simpson - International journal of cancer, 2000 - Wiley Online Library
Microsatellite instability (MSI) in tumors from patients with hereditary non‐polyposis
colorectal cancer (HNPCC) is caused by germline mutations in mismatch repair (MMR) …
colorectal cancer (HNPCC) is caused by germline mutations in mismatch repair (MMR) …
Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression
G Deng, A Chen, J Hong, HS Chae, YS Kim - Cancer research, 1999 - AACR
Microsatellite instability (MSI) has been described in tumors from patients with hereditary
nonpolyposis colorectal cancer, sporadic colorectal cancer, and other types of cancers. MSI …
nonpolyposis colorectal cancer, sporadic colorectal cancer, and other types of cancers. MSI …
Hypermethylation of the hMLH1 Gene Promoter in Human Gastric Cancers with Microsatellite Instability
AS Fleisher, M Esteller, S Wang, G Tamura, H Suzuki… - Cancer research, 1999 - AACR
Human gastric carcinoma shows a higher prevalence of microsatellite instability (MSI) than
does any other type of sporadic human cancer. The reasons for this high frequency of MSI …
does any other type of sporadic human cancer. The reasons for this high frequency of MSI …
hMSH6 Alterations in Patients with Microsatellite Instability-Low Colorectal Cancer
YR Parc, KC Halling, L Wang, ER Christensen… - Cancer research, 2000 - AACR
Two microsatellite instability (MSI) phenotypes have been described in colorectal cancer
(CRC): MSI-H (instability at> 30% of the loci examined) and MSI-L (MSI at 1–30% of the loci …
(CRC): MSI-H (instability at> 30% of the loci examined) and MSI-L (MSI at 1–30% of the loci …
[HTML][HTML] Methylation of hMLH1 promoter correlates with the gene silencing with a region-specific manner in colorectal cancer
G Deng, E Peng, J Gum, J Terdiman… - British journal of …, 2002 - nature.com
Microsatellite instability is present in over 80% of the hereditary non-polyposis colorectal
carcinoma and about 15–20% of the sporadic cancer. Microsatellite instability is caused by …
carcinoma and about 15–20% of the sporadic cancer. Microsatellite instability is caused by …
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite
instability (MSI) in colorectal cancer. We report that hypermethylation of the 5′ CpG island …
instability (MSI) in colorectal cancer. We report that hypermethylation of the 5′ CpG island …
A Hereditary Nonpolyposis Colorectal Carcinoma Case Associated with Hypermethylation of the MLH1 Gene in Normal Tissue and Loss of Heterozygosity of the …
I Gazzoli, M Loda, J Garber, S Syngal, RD Kolodner - Cancer research, 2002 - AACR
Fourteen suspected hereditary nonpolyposis colorectal carcinoma cases with microsatellite
unstable (microsatellite instability-high; MSI-H) tumors but no germ-line MSH2, MSH6, or …
unstable (microsatellite instability-high; MSI-H) tumors but no germ-line MSH2, MSH6, or …
Microsatellite instability and the role of hMSH2 in sporadic colorectalcancer.
VJ Bubb, LJ Curtis, C Cunningham, MG Dunlop… - Oncogene, 1996 - europepmc.org
Microsatellite instability (MSI) occurs in most tumours from patients with hereditary non-
polyposis colorectal cancer (HNPCC) and in around 17% of sporadic colorectal cancers …
polyposis colorectal cancer (HNPCC) and in around 17% of sporadic colorectal cancers …
Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers
SA Kuismanen, MT Holmberg, R Salovaara… - The American journal of …, 2000 - Elsevier
Microsatellite instability (MSI) is a hallmark of hereditary nonpolyposis colorectal cancer, and
in these patients, results from inherited defects in DNA mismatch repair genes, mostly MSH2 …
in these patients, results from inherited defects in DNA mismatch repair genes, mostly MSH2 …
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