Hypermethylation of the hMLH1 Promoter in Colon Cancer with Microsatellite Instability

JM Cunningham, ER Christensen, DJ Tester, CY Kim… - Cancer research, 1998 - AACR
Recent studies have demonstrated the presence of microsatellite instability (MSI) in tumors
from patients with hereditary nonpolyposis colon cancer and in a subset of patients with …

Methylation of the hMLH1 promoter but no hMLH1 mutations in sporadic gastric carcinomas with high‐level microsatellite instability

RAU Bevilacqua, AJG Simpson - International journal of cancer, 2000 - Wiley Online Library
Microsatellite instability (MSI) in tumors from patients with hereditary non‐polyposis
colorectal cancer (HNPCC) is caused by germline mutations in mismatch repair (MMR) …

Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression

G Deng, A Chen, J Hong, HS Chae, YS Kim - Cancer research, 1999 - AACR
Microsatellite instability (MSI) has been described in tumors from patients with hereditary
nonpolyposis colorectal cancer, sporadic colorectal cancer, and other types of cancers. MSI …

Hypermethylation of the hMLH1 Gene Promoter in Human Gastric Cancers with Microsatellite Instability

AS Fleisher, M Esteller, S Wang, G Tamura, H Suzuki… - Cancer research, 1999 - AACR
Human gastric carcinoma shows a higher prevalence of microsatellite instability (MSI) than
does any other type of sporadic human cancer. The reasons for this high frequency of MSI …

hMSH6 Alterations in Patients with Microsatellite Instability-Low Colorectal Cancer

YR Parc, KC Halling, L Wang, ER Christensen… - Cancer research, 2000 - AACR
Two microsatellite instability (MSI) phenotypes have been described in colorectal cancer
(CRC): MSI-H (instability at> 30% of the loci examined) and MSI-L (MSI at 1–30% of the loci …

[HTML][HTML] Methylation of hMLH1 promoter correlates with the gene silencing with a region-specific manner in colorectal cancer

G Deng, E Peng, J Gum, J Terdiman… - British journal of …, 2002 - nature.com
Microsatellite instability is present in over 80% of the hereditary non-polyposis colorectal
carcinoma and about 15–20% of the sporadic cancer. Microsatellite instability is caused by …

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

JG Herman, A Umar, K Polyak… - Proceedings of the …, 1998 - National Acad Sciences
Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite
instability (MSI) in colorectal cancer. We report that hypermethylation of the 5′ CpG island …

A Hereditary Nonpolyposis Colorectal Carcinoma Case Associated with Hypermethylation of the MLH1 Gene in Normal Tissue and Loss of Heterozygosity of the …

I Gazzoli, M Loda, J Garber, S Syngal, RD Kolodner - Cancer research, 2002 - AACR
Fourteen suspected hereditary nonpolyposis colorectal carcinoma cases with microsatellite
unstable (microsatellite instability-high; MSI-H) tumors but no germ-line MSH2, MSH6, or …

Microsatellite instability and the role of hMSH2 in sporadic colorectalcancer.

VJ Bubb, LJ Curtis, C Cunningham, MG Dunlop… - Oncogene, 1996 - europepmc.org
Microsatellite instability (MSI) occurs in most tumours from patients with hereditary non-
polyposis colorectal cancer (HNPCC) and in around 17% of sporadic colorectal cancers …

Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers

SA Kuismanen, MT Holmberg, R Salovaara… - The American journal of …, 2000 - Elsevier
Microsatellite instability (MSI) is a hallmark of hereditary nonpolyposis colorectal cancer, and
in these patients, results from inherited defects in DNA mismatch repair genes, mostly MSH2 …