Hydrogels in ophthalmology: Novel strategies for overcoming therapeutic challenges

KY Wu, D Akbar, M Giunta, A Kalevar, SD Tran - Materials, 2023 - mdpi.com
The human eye's intricate anatomical and physiological design necessitates tailored
approaches for managing ocular diseases. Recent advancements in ophthalmology …

Hydrogel-based ocular drug delivery systems: Emerging fabrication strategies, applications, and bench-to-bedside manufacturing considerations

RC Cooper, H Yang - Journal of controlled release, 2019 - Elsevier
The physiological barriers of the eye pose challenges to the delivery of the array of
therapeutics for ocular diseases. Hydrogels have been widely explored for medical …

Eye of the future: Unlocking the potential utilization of hydrogels in intraocular lenses

H Wu, J Wang, W Fan, Q Zhong, R Xue… - Bioengineering & …, 2024 - Wiley Online Library
Hydrogels are distinguished by their exceptional ability to absorb and retain large volumes
of water within their complex three‐dimensional polymer networks, which is advantageous …

Hydrogels for sustained delivery of biologics to the back of the eye

D Chang, K Park, A Famili - Drug Discovery Today, 2019 - Elsevier
Highlights•Hydrogels provide a flexible platform for design of ocular delivery
systems.•Intraocular injection of hydrogels can be accomplished via several …

Collagen-based hydrogels for the eye: A comprehensive review

D Rana, N Desai, S Salave, B Karunakaran, J Giri… - Gels, 2023 - mdpi.com
Collagen-based hydrogels have emerged as a highly promising platform for diverse
applications in ophthalmology, spanning from drug delivery systems to biomedical …

[HTML][HTML] Functionalized hydrogels in ophthalmic applications: Ocular inflammation, corneal injuries, vitreous substitutes and intravitreal injection

Q Gong, Y Zhao, T Qian, H Wang, Z Li - Materials & Design, 2022 - Elsevier
With the prevalence of eye diseases, such as inflamed eyes, corneal injury, cataract,
glaucoma, and retinal degenerative diseases, different clinical strategies have been …

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

M Kulbay, KY Wu, D Truong, SD Tran - Smart Molecules, 2024 - Wiley Online Library
This comprehensive review delves into a unique intersection of hydrogels as smart
molecules and their transformative applications in ophthalmology. Beginning with the …

Hydrogels-based ophthalmic drug delivery systems for treatment of ocular diseases

G Fang, X Yang, Q Wang, A Zhang, B Tang - Materials Science and …, 2021 - Elsevier
An increasing number of people worldwide are affected by eye diseases, eventually leading
to visual impairment or complete blindness. Conventional treatment involves the use of eye …

Applications and recent developments of Hydrogels in Ophthalmology

X Wang, FQ Li, X Liu, H Zhang - ACS Biomaterials Science & …, 2023 - ACS Publications
Hydrogels are a type of functional polymer material with a three-dimensional network
structure composed of physically or chemically cross-linked polymers. All hydrogels have …

Hydrogel-based ocular drug delivery systems for hydrophobic drugs

C Torres-Luna, X Fan, R Domszy, N Hu… - European Journal of …, 2020 - Elsevier
Conventional ophthalmic dosage forms such as eye drops pose a significant challenge
because physiological barriers and clearance mechanisms limit ocular bioavailability …