The tumor microenvironment (TME) is characterized by an acidic pH and low oxygen
concentrations. Hypoxia induces neoplastic cell evasion of the immune surveillance, rapid …

Hypoxia is a critical event in solid tumor development, invasion, and metastasis. Cellular
adaptation to hypoxic microenvironment is essential for tumor progression and is largely …

Low levels of oxygen or hypoxia is often an obstacle in health, particularly in pathological
disorders like cancer. The main family of transcription factors responsible for cell survival …

Hypoxia is a common feature in solid tumors and is associated with cancer progression. The
main regulators of the hypoxic response are hypoxia-inducible transcription factors (HIFs) …

Tumor microenvironment (TME), which is characterized by hypoxia, widely exists in solid
tumors. As a current research hotspot in the TME, hypoxia is expected to become a key …

A hypoxic microenvironment plays a critical role in the development and progression of
tumors. The epithelial to mesenchymal transition (EMT) is a process by which epithelial cells …

Background: Tumor hypoxia promotes cancer progression. Matrix metalloproteinases
(MMPs) are required for breast cancer cell invasion. Materials and Methods: The effect of …

Intratumoral hypoxia followed by stabilization/activation of hypoxia-inducible factor 1 (HIF-1)
and its downstream transcriptional factors, is one of the most important mechanisms …

Hypoxia, a condition of low oxygen tension in tissues, has emerged as a crucial factor in
tumor pathophysiology. Hypoxic microenvironment gives rise to altered cellular metabolism …

Simple Summary Cancer cells adapt to hypoxia, survive, and grow. To that aim, they engage
hypoxia-inducible pathways. These pathways are under intense investigation in search of …