Aloe/poloxamer hydrogel as an injectable β-estradiol delivery scaffold with multi-therapeutic effects to promote endometrial regeneration for intrauterine adhesion …

Q Yao, YW Zheng, QH Lan, LF Wang, ZW Huang… - European Journal of …, 2020 - Elsevier
Intrauterine adhesion (IUA) is characterized by endometrial stromal replaced with fibrous
tissue during the trauma or operation induced injury. Current clinic IUA management mainly …

Three-dimensional structure micelles of heparin-poloxamer improve the therapeutic effect of 17β-estradiol on endometrial regeneration for intrauterine adhesions in a …

SS Zhang, WT Xia, J Xu, HL Xu, CT Lu… - International journal …, 2017 - Taylor & Francis
Intrauterine adhesions (IUA) frequently occur after infectious or mechanical injury to the
endometrium, which may lead to infertility and/or pregnancy complications. There are few …

Sustained delivery of 17β-estradiol by human amniotic extracellular matrix (HAECM) scaffold integrated with PLGA microspheres for endometrium regeneration

Y Chen, W Fei, Y Zhao, F Wang, X Zheng, X Luan… - Drug Delivery, 2020 - Taylor & Francis
The endometrial injury usually results in intrauterine adhesions (IUAs). However, there is no
effective treatment to promote the regeneration of the endometrium currently. The …

Hydrogel, a novel therapeutic and delivery strategy, in the treatment of intrauterine adhesions

H Lv, B Wu, J Song, W Wu, W Cai, J Xu - Journal of Materials Chemistry …, 2021 - pubs.rsc.org
Intrauterine adhesions (IUAs) are caused by damage to the underlying lining of the
endometrium. They're related to disorder of endometrial repair. In recent years, hydrogels …

Using 17β‐estradiol heparin‐poloxamer thermosensitive hydrogel to enhance the endometrial regeneration and functional recovery of intrauterine adhesions in a rat …

SS Zhang, XX Xu, WW Xiang, HH Zhang… - The FASEB …, 2020 - Wiley Online Library
Mechanical damage or infection to the endometrium can lead to the formation of adhesions
in the uterine cavity, which may result in reduced reproductive outcome and/or pregnancy …

Bioactive Injectable and Self‐Healing Hydrogel Via Cell‐Free Fat Extract for Endometrial Regeneration

B Xu, M Zhou, M Liu, Z Wang, J Duan, W Li, W Cui… - Small, 2023 - Wiley Online Library
The damaged endometrium and the formation of fibrosis are key barriers to pregnancy and
further lead to infertility. However, how to promote endometrium repair is always a …

Sodium alginate hydrogel integrated with type III collagen and mesenchymal stem cell to promote endometrium regeneration and fertility restoration

Q Shuai, Y Liang, X Xu, Z Halbiyat, X Wang… - International Journal of …, 2023 - Elsevier
A thinner endometrium has been linked to implantation failure, and various therapeutic
strategies have been attempted to improve endometrial regeneration, including the use of …

An anti-fibroblast adhesion and anti-inflammatory hydrogel film combined with VEGF for intrauterine adhesion prevention

X Liu, H Wang, J She, Q Zhang, Q Hu, D Li… - Chemical Engineering …, 2023 - Elsevier
Intrauterine adhesions (IUA) are a common gynecologic disease worldwide that can lead to
menstrual irregularities, infertility, or repeated pregnancy loss. Biomaterials are used as a …

[HTML][HTML] Engineering self-healing adhesive hydrogels with antioxidant properties for intrauterine adhesion prevention

L Feng, L Wang, Y Ma, W Duan, S Martin-Saldaña… - Bioactive materials, 2023 - Elsevier
Intrauterine adhesion (IUA) is the fibrosis within the uterine cavity. It is the second most
common cause of female infertility, significantly affecting women's physical and mental …

[HTML][HTML] Recent developments in bio-scaffold materials as delivery strategies for therapeutics for endometrium regeneration

X Li, HF Lv, R Zhao, M Ying, AT Samuriwo, YZ Zhao - Materials Today Bio, 2021 - Elsevier
Intrauterine adhesions (IUAs) refer to the repair disorder after endometrial injury and may
lead to uterine infertility, recurrent miscarriage, abnormal menstrual bleeding, and other …