Heart failure affects nearly 6 million Americans, with a half-million new cases emerging each
year. Whereas up to 50% of heart failure patients die of arrhythmia, the diverse mechanisms …

In an attempt to compensate for compromised hemodynamics in heart failure, neurohumoral
mechanisms are activated that trigger fundamental changes in gene expression and in …

Background: Heart failure (HF) claims over 200,000 lives annually in the United States
alone. Approximately 50% of these deaths are sudden and unexpected, and presumably the …

Chronic heart failure is a clinical syndrome with multiple etiologies, associated with
significant morbidity and mortality. Cardiac arrhythmias, including ventricular …

Electrical remodeling of the heart takes place in response to both functional (altered
electrical activation) and structural (including heart failure and myocardial infarction) …

Background—Several arrhythmogenic mechanisms have been inferred from animal heart
failure models. However, the translation of these hypotheses is difficult because of the lack …

The mouse is the second mammalian species, after the human, in which substantial amount
of the genomic information has been analyzed. With advances in transgenic technology …

Background Heart failure is a final common pathway or descriptor for various cardiac
pathologies. It is associated with sudden cardiac death, which is frequently caused by …

Patients with heart failure experience a number of changes in the electrical function of the
heart that predispose to potentially lethal cardiac arrhythmias. Action potential prolongation …

Sudden cardiac death remains a leading cause of death in the Western world, accounting
for up to 20% of all deaths in the United States1, 2 The major causes of sudden cardiac …